Mediator Complex

A large protein complex which acts as a signaling adaptor protein that allows communication between the various regulatory and functional components of GENETIC TRANSCRIPTION including DNA POLYMERASE II; GENERAL TRANSCRIPTION FACTORS; and TRANSCRIPTION FACTORS that are bound to upstream ENHANCER ELEMENTS. The mediator complex was originally studied in YEAST where at least 21 subunits were identified. Many of the yeast subunits are homologs to proteins in higher organisms that are found associated with specific nuclear receptors such as THYROID HORMONE RECEPTORS and VITAMIN D RECEPTORS.

Also Known As:

Mediator Transcription Complex; Mediator-Like Complex; Mediator-Like Complexes; TR-Associated Protein (TRAP) Complex; TRAP (Thyroid Hormone Associated Protein) Complex; Thyroid Hormone-Associated Protein Complex; Mediator Like Complex; Mediator Like Complexes; Thyroid Hormone Associated Protein Complex

Macromolecular Substances: 97
- Multiprotein Complexes: 125
  - Mediator Complex: 200
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Carrier Proteins: 12999
    - Signal Transducing Adaptor Proteins
      - Mediator Complex: 200
  - Nuclear Proteins: 2678
    - Mediator Complex: 200
  - Intracellular Signaling Peptides and Proteins: 32
    - Signal Transducing Adaptor Proteins
      - Mediator Complex: 200
- Peptides: 82426
  - Intracellular Signaling Peptides and Proteins: 32
    - Signal Transducing Adaptor Proteins
      - Mediator Complex: 200

human MED14 protein

Bio-Agent Context: Research Results