human SLC22A5 protein

RefSeq NM_003060

Also Known As:

SLC22A5 protein, human; OCTN2 protein, human; organic cation transporter OCTN2; organic cation-carnitine transporter 2 protein, human; sodium-dependent high affinity carnitine transporter protein, human; solute carrier family 22 (organic cation transporter), member 5 protein, human

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Calarco, Anna: 1 article (10/2020)
2.	Di Cristo, Francesca: 1 article (10/2020)
3.	Digilio, Filomena Anna: 1 article (10/2020)
4.	Galderisi, Umberto: 1 article (10/2020)
5.	Melone, Mariarosa Anna Beatrice: 1 article (10/2020)
6.	Peluso, Gianfranco: 1 article (10/2020)
7.	Rosano, Camillo: 1 article (10/2020)
8.	Saturnino, Carmela: 1 article (10/2020)
9.	Sinicropi, Maria Stefania: 1 article (10/2020)
10.	Chang, Eugene B: 1 article (04/2011)

Related Diseases

1.	Mitochondrial Diseases (Mitochondrial Disease) 10/08/2020 - "We found that 3-(2,2,2-trimethylhydrazine)propionate (THP), which is able to reduce cellular carnitine levels by blocking both carnitine biosynthesis and the cell membrane carnitine/organic cation transporter (OCTN2), was reported to improve mitochondrial dysfunction in several diseases, such as Huntington's disease (HD). " 07/01/2010 - "Age-associated carnitine deficiency from a variety of etiologies, including organic cation transporter (OCTN2) mutation and carnitine palmitoyltransferase II (CPT) deficiency, may potentially explain the relationship between carnitine-associated mitochondrial dysfunction and geriatric frailty. "
2.	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 04/01/2011 - "The organic cation transporter OCTN2 is located on the IBD5 risk allele and has been implicated in the pathogenesis of inflammatory bowel diseases (IBD). "
3.	Myelodysplastic Syndromes (Myelodysplastic Syndrome) 07/01/2003 - "Downregulation of carnitine acyltransferases and organic cation transporter OCTN2 in mononuclear cells in healthy elderly and patients with myelodysplastic syndromes."
4.	Huntington Disease (Huntington's Disease) 10/08/2020 - "We found that 3-(2,2,2-trimethylhydrazine)propionate (THP), which is able to reduce cellular carnitine levels by blocking both carnitine biosynthesis and the cell membrane carnitine/organic cation transporter (OCTN2), was reported to improve mitochondrial dysfunction in several diseases, such as Huntington's disease (HD). "
5.	Frailty 07/01/2010 - "Age-associated carnitine deficiency from a variety of etiologies, including organic cation transporter (OCTN2) mutation and carnitine palmitoyltransferase II (CPT) deficiency, may potentially explain the relationship between carnitine-associated mitochondrial dysfunction and geriatric frailty. "

Related Drugs and Biologics

1.	Carnitine (L-Carnitine)
2.	Carnitine O-Palmitoyltransferase (Carnitine Palmitoyltransferase II)
3.	Carnitine Acyltransferases (Carnitine-Acylcarnitine Translocase)
4.	3-(2,2,2-trimethylhydrazine)propionate
5.	2- cyclohexylidenhydrazo- 4- phenyl- thiazole