9-hydroxypheophorbide alpha

chlorophyll-derived photosensitizer

Networked: 4 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Pyrroles: 369
      - Tetrapyrroles: 70
        Chlorophyll: 1072
        9-hydroxypheophorbide alpha: 4
- Fused-Ring Heterocyclic Compounds
  - 4 or More Rings Heterocyclic Compounds
    - Tetrapyrroles: 70
      - Chlorophyll: 1072
        9-hydroxypheophorbide alpha: 4
Polycyclic Compounds: 6
- Macrocyclic Compounds: 15
  - Tetrapyrroles: 70
    - Chlorophyll: 1072
      - 9-hydroxypheophorbide alpha: 4

Experts

1.	Ahn, Jin-Chul: 3 articles (04/2010 - 02/2009)
2.	Chung, Phil-Sang: 3 articles (04/2010 - 02/2009)
3.	He, Peijie: 3 articles (04/2010 - 02/2009)
4.	Shin, Jang-In: 3 articles (04/2010 - 02/2009)
5.	Hwang, Hee-Jun: 2 articles (07/2009 - 02/2009)
6.	Lee, Sang Joon: 1 article (07/2009)
7.	Kang, Jung-Wook: 1 article (02/2009)
8.	Lee, Sang-Joon: 1 article (02/2009)
9.	Cho, Jeong-Woo: 1 article (01/2004)
10.	Choi, Sung-E: 1 article (01/2004)

Related Diseases

1.	Head and Neck Neoplasms (Head and Neck Cancer) 07/01/2009 - "Photodynamic therapy with 9-hydroxypheophorbide alpha on AMC-HN-3 human head and neck cancer cells: induction of apoptosis via photoactivation of mitochondria and endoplasmic reticulum." 02/01/2009 - "Enhanced apoptotic effect of combined modality of 9-hydroxypheophorbide alpha-mediated photodynamic therapy and carboplatin on AMC-HN-3 human head and neck cancer cells." 02/01/2009 - "In this study, we investigated the cytotoxic and apoptotic effect of combined modality of 9-hydroxypheophorbide alpha (9-HPbD)-mediated PDT and CBDCA on AMC-HN-3 human head and neck cancer cell line in vitro. "
2.	Neoplasms (Cancer) 07/01/2009 - "In this study, we investigated the mechanism of PDT mediated by a new chlorophyll derivative photosensitizer, 9-hydroxypheophorbide alpha (9-HPbD), on AMC-HN-3 cancer cells. "
3.	Laryngeal Neoplasms (Laryngeal Cancer) 04/01/2010 - "Photoactivation of 9-hydroxypheophorbide alpha triggers apoptosis through the reactive oxygen species-mediated mitochondrial pathway and endoplasmic reticulum stress in AMC-HN-3 laryngeal cancer cells." 04/01/2010 - "Recently, we demonstrated that a combination modality of 9-hydroxypheophorbide alpha (9-HPbD)-based PDT and carboplatin exerts enhanced cytotoxic and apoptotic effects on AMC-HN-3 laryngeal cancer cells. "
4.	Breast Neoplasms (Breast Cancer) 01/23/2004 - "9-Hydroxypheophorbide alpha-induced apoptotic death of MCF-7 breast cancer cells is mediated by c-Jun N-terminal kinase activation."

Related Drugs and Biologics

1.	1-phenyl-3,3-dimethyltriazene (PDT)
2.	Carboplatin (JM8)
3.	Photosensitizing Agents (Photosensitizers)
4.	Chlorophyll
5.	JNK Mitogen-Activated Protein Kinases
6.	Reactive Oxygen Species (Oxygen Radicals)

Related Therapies and Procedures

1.	Photochemotherapy (Photodynamic Therapy)