MEA regimen

chemotherapy protocol consisting of above cpds for treatment of high-risk gestational trophoblastic tumor

Networked: 3 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Therapy Context: Research Results

Therapeutics: 1158551
- Drug Therapy: 293145
  - Combination Drug Therapy: 12066
    - Antineoplastic Combined Chemotherapy Protocols: 35
      - MEA regimen: 3
  - Antineoplastic Protocols: 55
    - Antineoplastic Combined Chemotherapy Protocols: 35
      - MEA regimen: 3
- Clinical Protocols
  - Antineoplastic Protocols: 55
    - Antineoplastic Combined Chemotherapy Protocols: 35
      - MEA regimen: 3
Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Pteridines: 147
      - Pterins: 160
        Folic Acid: 19425
        Tetrahydrofolates: 8
        Formyltetrahydrofolates
        Leucovorin: 5743
        MEA regimen: 3
        Aminopterin: 248
        Methotrexate: 24010
        MEA regimen: 3
  - 3-Ring Heterocyclic Compounds
    - Dactinomycin: 2073
      - MEA regimen: 3
Enzymes and Coenzymes: 1
- Coenzymes: 558
  - Tetrahydrofolates: 8
    - Formyltetrahydrofolates
      - Leucovorin: 5743
        MEA regimen: 3
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Naphthalenes: 18
    - Tetrahydronaphthalenes: 1
      - Podophyllotoxin: 562
        Etoposide: 10706
        MEA regimen: 3
- Macrocyclic Compounds: 15
  - Cyclic Peptides: 530
    - Dactinomycin: 2073
      - MEA regimen: 3
Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Cyclic Peptides: 530
    - Dactinomycin: 2073
      - MEA regimen: 3
Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Polycyclic Aromatic Hydrocarbons: 2020
        Naphthalenes: 18
        Tetrahydronaphthalenes: 1
        Podophyllotoxin: 562
        Etoposide: 10706
        MEA regimen: 3
Carbohydrates: 22023
- Glycosides: 2119
  - Glucosides: 639
    - Etoposide: 10706
      - MEA regimen: 3

Experts

1.	Fujisawa, Masato: 1 article (10/2010)
2.	Miyake, Hideaki: 1 article (10/2010)
3.	Muramaki, Mototsugu: 1 article (10/2010)
4.	Takenaka, Atsushi: 1 article (10/2010)
5.	Terakawa, Tomoaki: 1 article (10/2010)
6.	Iitsuka, Yoshinori: 1 article (06/2004)
7.	Matsui, Hideo: 1 article (06/2004)
8.	Mitsuhashi, Akira: 1 article (06/2004)
9.	Sekiya, Souei: 1 article (06/2004)
10.	Suzuka, Kiyomi: 1 article (06/2004)

Related Diseases

1.	Neoplasm Metastasis (Metastasis) 07/01/2000 - "After treatment with the MEA regimen, 29 of 39 patients achieved primary remission (74.4%), 8 developed resistance (20.5%), and 2 died of widespread metastases and chemotherapy-related toxicity. "
2.	Trophoblastic Neoplasms (Trophoblastic Tumor) 07/01/2000 - "The goal of this study was to evaluate the efficacy, toxicity, and survival of patients with high-risk gestational trophoblastic tumors (GTTs) treated with a methotrexate-etoposide-actinomycin D (MEA) regimen without cyclosphosphamide or vincristine. " 06/01/2004 - "To evaluate the efficacy and safety of etoposide/methotrexate/actinomycin D (MEA regimen) as initial chemotherapy and 5-fluorouracil/actinomycin D (FA regimen) as salvage chemotherapy for high-risk gestational trophoblastic tumor (GTT). "
3.	Thrombocytopenia (Thrombopenia) 07/01/2000 - "WHO grade 4 leukocytopenia and thrombocytopenia with the MEA regimen occurred in 5.3 and 6.4%, respectively, of the cycles; other toxic effects were acceptable and manageable. "
4.	Leukopenia 07/01/2000 - "WHO grade 4 leukocytopenia and thrombocytopenia with the MEA regimen occurred in 5.3 and 6.4%, respectively, of the cycles; other toxic effects were acceptable and manageable. "
5.	Choriocarcinoma 10/01/2010 - "Considering the current outcomes, MEA regimen could be an attractive option as a salvage chemotherapy for metastatic NSGCT patients with a choriocarcinoma component showing resistance to intensive conventional chemotherapies."

Related Drugs and Biologics

1.	Methotrexate (Mexate)
2.	Etoposide (VP 16)
3.	Dactinomycin (Actinomycin)
4.	Vincristine (Oncovin)
5.	Fluorouracil (Carac)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Aftercare (After-Treatment)