Mannose-Binding Protein-Associated Serine Proteases

Serum serine proteases which participate in COMPLEMENT ACTIVATION. They are activated when complexed with the MANNOSE-BINDING LECTIN, therefore also known as Mannose-binding protein-Associated Serine Proteases (MASPs). They cleave COMPLEMENT C4 and COMPLEMENT C2 to form C4b2a, the CLASSICAL PATHWAY C3 CONVERTASE.

Also Known As:

Mannose-Binding Protein-Associated Serine Protease; MASP Proteases; MASP-Related Protein; MASPs; MBL-Associated Serine Proteases; MBP-Associated Serine Protease; MBP-Associated Serine Protease-Related Protein; Mannan-Binding Lectin Serine Proteases; MASP Related Protein; MBL Associated Serine Proteases; MBP Associated Serine Protease; MBP Associated Serine Protease Related Protein; Mannan Binding Lectin Serine Proteases; Mannose Binding Protein Associated Serine Protease; Proteases, MASP; Protein, MASP-Related; Serine Protease, MBP-Associated; Serine Proteases, MBL-Associated; MASP

Pharmalogical Action Categories:

Immunologic Factors

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Peptide Hydrolases: 23957
      - Serine Proteases: 3726
        Serine Endopeptidases: 11
        Mannose-Binding Protein-Associated Serine Proteases: 78
      - Endopeptidases: 633
        Serine Endopeptidases: 11
        Mannose-Binding Protein-Associated Serine Proteases: 78
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Blood Proteins: 12459
    - Immunoproteins: 43
      - Complement System Proteins: 33379
        Complement Activating Enzymes
        Complement C3-C5 Convertases: 87
        Mannose-Binding Protein-Associated Serine Proteases: 78

mouse MASP-2 protein

Bio-Agent Context: Research Results