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cilobradine

has bradycardic activity

Networked: 5 relevant articles (2 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Piperidines: 17
    - cilobradine: 5
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzazepines: 5
      - cilobradine: 5

Experts

1.	Albrecht, B: 1 article (06/2022)
2.	Bomassi, E: 1 article (06/2022)
3.	Bracke, A: 1 article (06/2022)
4.	Den Hertog, E: 1 article (06/2022)
5.	Dukes-McEwan, J: 1 article (06/2022)
6.	Eichhorn, G: 1 article (06/2022)
7.	French, A: 1 article (06/2022)
8.	Höpfner, R: 1 article (06/2022)
9.	Kirsch, A: 1 article (06/2022)
10.	Little, C J L: 1 article (06/2022)

Related Diseases

1.	Bradycardia 05/01/2007 - "High-dose cilobradine effectively produced bradycardia and improved cardiac function after CHF, comparable with metoprolol. " 03/01/2004 - "The present results confirm the notion that cilobradine is more effective than zatebradine in inducing bradycardia. " 05/01/2007 - "This study tested the relative importance of bradycardia by comparing cilobradine (Cilo), a sinus node inhibitor, with a beta-blocker, metoprolol (Meto), in an established canine model of CHF. " 04/01/2006 - "In addition to bradycardia, all three drugs induced increasing arrhythmia at concentrations greater than 5 mg/kg for cilobradine, greater than 10 mg/kg for zatebradine, or greater than 15 mg/kg for ivabradine. "
2.	Coronary Occlusion 12/01/2004 - "After 60 min coronary occlusion and 30 min reperfusion, both systolic and diastolic ventricular function were more reduced in the cilobradine group; i.e. "
3.	Myocardial Infarction 12/01/2004 - "We examined the contribution of heart rate reduction by cilobradine (DK-AH 269), a direct sinus node inhibitor, on left ventricular function and peripheral vasomotion in anesthetized rabbits with experimental myocardial infarction. "
4.	Cardiomyopathies (Cardiomyopathy) 06/01/2022 - "Effect of cilobradine in cats with a first episode of congestive heart failure due to primary cardiomyopathy."
5.	Infarction (Infarctions) 12/01/2004 - "In conclusion, cilobradine reduced heart rate without any negative inotropic effect and reduced infarct size. " 12/01/2004 - "However, infarct size in the cilobradine group was significantly smaller compared with the placebo group. "

Related Drugs and Biologics

1.	Metoprolol (Toprol-XL)
2.	zatebradine
3.	Cytidine Monophosphate (CMP)
4.	Ivabradine