icilin

09/01/2012 - "Topical TRPM8 agonist (icilin) relieved vulva pruritus originating from lichen sclerosus et atrophicus."

09/01/2012 - "Topical TRPM8 agonist (icilin) relieved vulva pruritus originating from lichen sclerosus et atrophicus."

11/29/2013 - "In this study, we found that icilin, a super-cooling agent, down-regulated the expression of cell cycle signature genes and caused G1 arrest in PC-3 prostate cancer cells. "
03/04/2011 - "In this study, we demonstrated that icilin, a cooling compound, induces G1 arrest in PC-3 prostate cancer cells without cell death. "
11/29/2013 - "These results demonstrated that icilin inactivates a small regulatory module controlling the cell cycle in prostate cancer cells. "
11/29/2013 - "Icilin inhibits E2F1-mediated cell cycle regulatory programs in prostate cancer."
03/04/2011 - "Our findings suggest that icilin is a valuable chemical probe for future investigation aiming at delineating the molecular mechanisms of cell cycle regulation in prostate cancer."

06/18/2008 - "Comparison of icilin- and cold-evoked responses of spinal neurones, and their modulation of mechanical activity, in a model of neuropathic pain."
04/04/2014 - "The aim of this study was to analyze the modulation of ICa(V) by the TRPM8-agonist icilin in vitro and to investigate the analgesic effect of icilin in a neuropathic pain model in vivo. "

11/01/2023 - "In the present study, we investigated whether icilin, a TRPM8 agonist, was a target for the suppression of sickness responses using a mouse model of LPS-induced sepsis. "
11/01/2023 - "Therefore, the present results demonstrated that the icilin pretreatment alleviated LPS-induced sickness responses or decreases in body temperature, locomotor activity, body weight loss, and food and water intakes, suggesting its potential as a therapeutic target for sepsis."