|1.||Kim, Su-Hwa: 2 articles (11/2013 - 03/2011)|
|2.||Jeon, Ju-Hong: 2 articles (11/2013 - 03/2011)|
|3.||So, Insuk: 2 articles (11/2013 - 03/2011)|
|4.||Nakamura, E: 2 articles (12/2008 - 10/2007)|
|5.||Kubo, Y: 2 articles (12/2008 - 10/2007)|
|6.||Hayashi, S: 2 articles (12/2008 - 10/2007)|
|7.||Takeuchi, K: 2 articles (12/2008 - 10/2007)|
|8.||Cucu, Dana: 1 article (07/2014)|
|9.||Petrescu, Stefana: 1 article (07/2014)|
|10.||Chiritoiu, Gabriela: 1 article (07/2014)|
|1.||Lichen Sclerosus et Atrophicus (Lichen Sclerosus)
|3.||Prostatic Neoplasms (Prostate Cancer)
11/29/2013 - "In this study, we found that icilin, a super-cooling agent, down-regulated the expression of cell cycle signature genes and caused G1 arrest in PC-3 prostate cancer cells. "
03/04/2011 - "In this study, we demonstrated that icilin, a cooling compound, induces G1 arrest in PC-3 prostate cancer cells without cell death. "
11/29/2013 - "These results demonstrated that icilin inactivates a small regulatory module controlling the cell cycle in prostate cancer cells. "
11/29/2013 - "Icilin inhibits E2F1-mediated cell cycle regulatory programs in prostate cancer."
03/04/2011 - "Our findings suggest that icilin is a valuable chemical probe for future investigation aiming at delineating the molecular mechanisms of cell cycle regulation in prostate cancer."
|4.||Neuralgia (Stump Neuralgia)
04/04/2014 - "The aim of this study was to analyze the modulation of ICa(V) by the TRPM8-agonist icilin in vitro and to investigate the analgesic effect of icilin in a neuropathic pain model in vivo. "
06/18/2008 - "Comparison of icilin- and cold-evoked responses of spinal neurones, and their modulation of mechanical activity, in a model of neuropathic pain."
01/14/2008 - "Our experiments revealed that icilin (2.5, 5, 7.5 and 10 mg/kg, i.m.) elicits a dose-related hyperthermia that is rapid in onset and of long duration. "
01/14/2008 - "These results indicate that icilin, a TRPM8/TRPA1 agonist, produces a dose-related hyperthermia in rats which requires both NO production and NMDA receptor activation."
01/14/2008 - "Pretreating rats with N(G)-nitro-L-arginine methyl ester hydrochloride (L-NAME) (10, 25 and 50 mg/kg, i.p.), a non-selective NO synthase inhibitor, attenuated the hyperthermia associated with icilin (7.5 mg/kg, i.m.). "
01/14/2008 - "Icilin induces a hyperthermia in rats that is dependent on nitric oxide production and NMDA receptor activation."
01/14/2008 - "Therefore, in the present study we investigated the effects of icilin on body temperature in rats and tested the hypothesis that cold-activated TRP channel activation by icilin causes a hyperthermia which requires nitric oxide (NO) production and NMDA receptor stimulation. "
|1.||TRPC Cation Channels
|3.||Nitric Oxide (Nitrogen Monoxide)
|5.||E2F1 Transcription Factor
|6.||NG-Nitroarginine Methyl Ester (L-NAME)
|7.||Nitric Oxide Synthase (NO Synthase)
|8.||Messenger RNA (mRNA)