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mouse Map3k8 protein

Tpl-2 is thehomolog of human cot; a MAP3K kinase involved in the progression of rodent T-cell lymphomas & in T-cell activation; it up-regulates COX-2 gene expression in Jurkat T cells; It binds and induces NF-B-dependent transcription; RefSeq NM_007746
Also Known As:
Map3k8 protein, mouse; Tpl-2 protein, mouse; c-COT protein, mouse; cancer osaka thyroid kinase, mouse; mitogen activated protein kinase kinase kinase 8, mouse; sluggish protein, mouse; tumor progression locus 2 protein, mouse
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Bio-Agent Context: Research Results