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potassium oxonate

used to induce hyperuricemia in mice
Networked: 227 relevant articles (10 outcomes, 53 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Zhang, Yi: 5 articles (05/2022 - 03/2018)
2. Dai, Xiwen: 5 articles (01/2021 - 11/2019)
3. Mao, Qing: 5 articles (01/2021 - 11/2019)
4. Wang, Shaojie: 5 articles (01/2021 - 11/2019)
5. Zhang, Bing: 5 articles (01/2021 - 11/2019)
6. Kong, Ling-Dong: 5 articles (01/2015 - 01/2010)
7. Wang, Tao: 4 articles (05/2022 - 03/2018)
8. Yu, Haiyang: 4 articles (05/2022 - 03/2018)
9. Kim, Dong-Seon: 4 articles (01/2022 - 12/2018)
10. Li, Jing: 4 articles (01/2022 - 11/2017)

Related Diseases

1. Hyperuricemia
2. Colorectal Neoplasms (Colorectal Cancer)
06/01/2004 - "The goal of the current study was to evaluate the objective response rate and toxicity associated with the oral fluoropyrimidine S-1 (a combination of tegafur, 5-chloro-2,4-dihydroxypyridine, and potassium oxonate) in patients with previously untreated metastatic colorectal carcinoma. "
06/01/1996 - "The purpose of this study was to establish a nude rat orthotopic (organ-specific) human colorectal cancer model as an in vivo secondary screen for general evaluation of new anticancer agents against colorectal cancer and to evaluate practically the antitumor activity of 1 M tegafur-0.4 M 5-chloro-2,4-dihydroxypyridine-1 M potassium oxonate (S-1), a new p.o. "
09/01/2010 - "We therefore planned an open-label randomised controlled trial to verify the non-inferiority of irinotecan plus oral S-1 (a combination of tegafur, 5-chloro-2,4-dihydroxypyridine, and potassium oxonate; IRIS) to FOLFIRI as second-line chemotherapy for metastatic colorectal cancer. "
08/18/2008 - "In this study, we examined the antitumor activity of 5-Fluorouracil (5-FU)-based drugs (S-1 [1M tegafur, 0.4M 5-chloro-2,4-dihydroxypyridine and 1M potassium oxonate] and capecitabine) on human colorectal cancer xenografts and evaluated their anti-angiogenic effects. "
07/01/2000 - "This study set out to evaluate, in patients with metastatic colorectal carcinoma, the efficacy and toxicity of S-1, which contains tegafur, 5-chloro-2,4-dihydroxypyridine (CDHP) and potassium oxonate, based on a biochemical modulation of 5-fluorouracil (5-FU) targeted at inhibition of dihydropyrimidine dehydrogenase (DPD). "
3. Neoplasms (Cancer)
06/01/2006 - "S-1 is a newly developed oral anti-tumor agent, which contains 5-chloro-2, 4-dihydroxypyridine and potassium oxonate to strengthen biological activities of 5-fluorouracil. "
10/01/1999 - "Therefore, to overcome these metabolic events, S-1, an antitumor agent was developed, based on the biochemical modulation of FT by 5-chloro-2,4-dihydroxypyridine (CDHP) and potassium oxonate (Oxo), in a molar ratio of 1:0.4:1. The antineoplastic effect of S-1, was examined in Japanese patients with advanced gastric (G) or colorectal (C) cancer in a multicenter early phase II study involving 24 centers throughout Japan. "
08/05/2001 - "The usefulness of the method was demonstrated by the analysis of the F-beta-alanine and beta-alanine concentrations in plasma and urine samples from tumor patients treated with S-1 (Tegafur, 5-chloro-2,4-dihydroxypyridine and potassium oxonate in a molar ratio of 1:0.4:1)."
11/01/2005 - "The combination of S-1, consisting of 1 mol/l tegafur, 0.4 mol/l 5-chloro-2,4-dihydroxypyridine and 1 mol/l potassium oxonate, plus low-dose cisplatin has showed promising anti-tumor activities in experimental and clinical studies. "
07/01/2005 - "The purposes of this study were to evaluate the antitumor activity of S-1 (1 M tegafur, 0.4 M 5-chloro-2,4-dihydroxypyridine and 1 M potassium oxonate) on human lung tumor xenografts, as compared with other fluoro-pyrimidines, and to investigate the relationships between fluoropyrimidine antitumor activities and four distinct enzymatic activities involved in the phosphorylation and degradation pathways of 5-fluorouracil (5-FU) metabolism. "
4. Inflammation (Inflammations)
5. Gout

Related Drugs and Biologics

1. Uric Acid (Urate)
2. Adenine
3. Tegafur
4. gimeracil
5. Fluorouracil (Carac)
6. Xanthine Oxidase
7. Antineoplastic Agents (Antineoplastics)
8. Prodrugs
9. Gout Suppressants (Antigout Agents)
10. Creatinine

Related Therapies and Procedures

1. Oral Administration
2. Therapeutics
3. Drug Therapy (Chemotherapy)
4. Chinese Traditional Medicine (Traditional Chinese Medicine)
5. Adjuvant Chemotherapy