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IPX 750

has antiparkinson activity; structure in first source, but nature of linkage with glucose is unclear

Also Known As:

IPX-750; IPX750

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Christian, Samuel T: 1 article (03/2004)
2.	Jankovic, Joseph: 1 article (03/2004)
3.	Jiang, Chuantao: 1 article (03/2004)
4.	Le, Weidong: 1 article (03/2004)
5.	Niznik, Hyman B: 1 article (03/2004)
6.	Pristupa, Zdenek B: 1 article (03/2004)
7.	Sundsmo, John S: 1 article (03/2004)
8.	Wan, Xinhua: 1 article (03/2004)

Related Diseases

1.	Parkinson Disease (Parkinson's Disease) 03/01/2004 - "Dopaminergic properties and experimental anti-parkinsonian effects of IPX750 in rodent models of Parkinson disease." 03/01/2004 - "IPX-750 was evaluated in the Parkinson's disease animal models, including MPTP mouse model, the 6-hydroxydopamine (6-OHDA) rat model and the Nurr1(+/-) knockout mouse model. "
2.	Deficiency Diseases (Deficiency Disease) 03/01/2004 - "These combined results suggest (i) that stereo-specific glycoconjugation may be an effective method to improve penetrability of drugs through the blood brain barrier; (ii) treatment with bioavailable IPX-750 in vitro did not show evidence for neurotoxicity; and, (iii) IPX-750 possesses dopaminergic properties and exerts anti-parkinsonian effects in three different PD rodent models, suggesting therapeutic potential for this new class of drugs in treating dopamine deficiency diseases."

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