acetyl- lysyl- prolyl- seryl- seryl- prolyl- prolyl- glutamyl- glutamic acid amide

authors use symbol for angstrom instead of the letter A in the name of the peptide

Also Known As:

A6 peptide; Ac-KPSSPPEE-NH2; Ac-Lys-Pro-Ser-Ser-Pro-Pro-Glu-Glu-NH2; urokinase plasminogen activator (136-143), human

Networked: 7 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Zhong, Zhiyuan: 3 articles (01/2022 - 01/2020)
2.	Meng, Fenghua: 2 articles (01/2022 - 10/2021)
3.	Howell, Stephen B: 2 articles (06/2012 - 11/2011)
4.	Guo, Beibei: 1 article (01/2022)
5.	Sun, Yinping: 1 article (01/2022)
6.	Wang, Jingyi: 1 article (01/2022)
7.	Wei, Jingjing: 1 article (01/2022)
8.	Yuan, Jiandong: 1 article (01/2022)
9.	Cornelissen, Jeroen J L M: 1 article (10/2021)
10.	Fan, Daoyang: 1 article (10/2021)

Related Diseases

1.	Neoplasms (Cancer) 11/01/2011 - "The A6 peptide (acetyl-KPSSPPEE-amino) has antitumor activity in the absence of significant adverse events in murine tumor models and clinical trials. " 01/01/2022 - "The short A6 peptide (sequence: Ac-KPSSPPEE-NH2) is clinically validated for specific binding to CD44 on metastatic tumors. " 01/01/2022 - "Here, we designed a robust and CD44-specific GEM nanotherapeutics by encapsulating hydrophobic phosphorylated gemcitabine prodrug (HPG) into the core of A6 peptide-functionalized disulfide-crosslinked micelles (A6-mHPG), which exhibited reduction-triggered HPG release and specific targetability to CD44 overexpressing tumor cells. "
2.	Carcinoma (Carcinomatosis) 06/01/2012 - "This multi-institutional phase II trial assessed the activity and tolerability of the anti-metastatic A6 peptide that binds CD44 in patients with persistent or recurrent epithelial ovarian, fallopian tube, or primary peritoneal carcinoma (EOC/FTC/PPC). "
3.	Retinal Neovascularization 06/01/2003 - "Histologic analysis of mice treated with A6 peptide showed significant inhibition of retinal neovascularization, and the response was dose dependent. "
4.	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 10/01/2021 - "A6 peptide-tagged, ultra-small and reduction-sensitive polymersomal vincristine sulfate as a smart and specific treatment for CD44+ acute myeloid leukemia."
5.	Neoplasm Metastasis (Metastasis) 11/01/2011 - "A6 peptide activates CD44 adhesive activity, induces FAK and MEK phosphorylation, and inhibits the migration and metastasis of CD44-expressing cells."

Related Drugs and Biologics

1.	Racivir
2.	Micelles
3.	Disulfides
4.	Proteasome Inhibitors
5.	Mitogen-Activated Protein Kinase Kinases (MEKs)
6.	Small Nuclear Ribonucleoproteins (snRNP)
7.	Vincristine (Oncovin)
8.	Prodrugs
9.	Peptides (Polypeptides)
10.	Autoantigens