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IC 486068

inhibits the p110delta subunit of PI3K

Also Known As:

IC-486068; IC486068

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinazolines: 402
      - IC 486068: 1

Experts

1.	Brousal, Jeffrey: 1 article (07/2004)
2.	Cuneo, Kyle: 1 article (07/2004)
3.	Fu, Allie: 1 article (07/2004)
4.	Geng, Ling: 1 article (07/2004)
5.	Hallahan, Dennis E: 1 article (07/2004)
6.	Hayflick, Joel S: 1 article (07/2004)
7.	Himmelfarb, Eric: 1 article (07/2004)
8.	Kesicki, Edward A: 1 article (07/2004)
9.	Niermann, Ken: 1 article (07/2004)
10.	Schueneman, Aaron: 1 article (07/2004)

Related Diseases

1.

Neoplasms (Cancer)

07/15/2004 - "The vascular length density was measured by use of the tumor vascular window model and showed IC486068 significantly enhanced radiation-induced destruction of tumor vasculature as compared with either treatment alone. "
07/15/2004 - "Combined treatment with IC486068 and radiation significantly reduced tumor volume as compared with either treatment alone. "
07/15/2004 - "IC486068 enhances radiation-induced endothelial cytotoxicity, resulting in tumor vascular destruction and tumor control when combined with fractionated radiotherapy in murine tumor models. "
07/15/2004 - "A specific antagonist of the p110delta catalytic component of phosphatidylinositol 3'-kinase, IC486068, enhances radiation-induced tumor vascular destruction."

Related Drugs and Biologics

1.	Phosphatidylinositols (Phosphatidylinositol)

Related Therapies and Procedures

1.	Radiotherapy