1,2,3,4,4a,5,10,10a- octahydro- 6- methoxy- 1- methylbenz(g)quinoline- 3- carboxylic acid 4-(4-nitrophenyl)piperazine amide

a somatostatin sst1 receptor antagonist; structure in first source

Also Known As:

1,2,3,4,4a,5,10,10a-octahydro-6-methoxy-1-methylbenz(g)quinoline-3-carboxylic acid 4-(4-nitrophenyl)piperazine amide hydrogen malonate; SRA 880; SRA-880; SRA880

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Piperazines: 26
    - 1,2,3,4,4a,5,10,10a-octahydro-6-methoxy-1-methylbenz(g)quinoline-3-carboxylic acid 4-(4-nitrophenyl)piperazine amide: 2
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinolines: 146
      - 1,2,3,4,4a,5,10,10a-octahydro-6-methoxy-1-methylbenz(g)quinoline-3-carboxylic acid 4-(4-nitrophenyl)piperazine amide: 2

Experts

1.	Hoyer, Daniel: 2 articles (03/2010 - 11/2004)
2.	Aourz, Najat: 1 article (03/2010)
3.	Clinckers, Ralph: 1 article (03/2010)
4.	De Bundel, Dimitri: 1 article (03/2010)
5.	Kastellakis, Andreas: 1 article (03/2010)
6.	Kiagiadaki, Foteini: 1 article (03/2010)
7.	Michotte, Yvette: 1 article (03/2010)
8.	Smolders, Ilse: 1 article (03/2010)
9.	Thermos, Kyriaki: 1 article (03/2010)
10.	Bagnoli, Paola: 1 article (11/2004)

Related Diseases

1.	Seizures (Absence Seizure) 03/10/2010 - "SRA880 did not affect seizure severity and did not reverse the anticonvulsive action of SRIF-14 (1 microM) against pilocarpine-induced seizures, suggesting that hippocampal sst(1) receptors are not involved in the anticonvulsive effects of SRIF-14."
2.	Epilepsy (Aura) 11/01/2004 - "Activation of sst2 does not affect the bursting frequency unless its agonist octreotide is applied with SRA-880, indicating that sst1 masks sst2-mediated modulation of epilepsy. " 11/01/2004 - "In WT mice, SRIF and the sst1 agonist CH-275 reduce epilepsy whereas sst1 blockade with its antagonist SRA-880 increases the bursting discharge. " 11/01/2004 - "In sst1 KO mice: (i) the bursting frequency is lower than in WT; (ii) SRIF, CH-275 and SRA-880 are ineffective on epilepsy and (iii) octreotide is also devoid of effects, whereas blockade of sst2 with the antagonist D-Tyr8 Cyn 154806 increases the bursting frequency. "

Related Drugs and Biologics

1.	Octreotide (Sandostatin)
2.	Pilocarpine (Ocusert)
3.	CYN 154806
4.	CH 275