|1.||Shinkai, Hisashi: 1 article (07/2004)|
|2.||Komatsu, Norio: 1 article (07/2004)|
|3.||Oda, Tomohiro: 1 article (07/2004)|
|4.||Inagaki, Koji: 1 article (07/2004)|
|5.||Naka, Yuichi: 1 article (07/2004)|
|6.||Iwamura, Hiroyuki: 1 article (07/2004)|
07/01/2004 - "These data suggest that JTZ-132 is a novel stimulator of megakaryocytopoiesis and thrombocytopoiesis in vitro and in vivo with TPO mimetic activities and that it is useful for the treatment of thrombocytopenia."
07/01/2004 - "We report in this paper that a novel small molecule, JTZ-132, induced growth and differentiation of megakaryocytic progenitor cells and improved thrombocytopenia in myelosuppressed mice. "
07/01/2004 - "JTZ-132 stimulated proliferation of UT-7/TPO cells, a cell line highly sensitive to thrombopoietin (TPO), and exhibited full efficacy comparable to TPO with an approximate EC(50) (median effective concentration) value of 0.43 microM, whereas little proliferation was observed in a TPO-insensitive cell line, UT-7/EPO, and human carcinoma cell line, HCT116. "
|1.||Thrombopoietin (c-mpl Ligand)