HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

squalamine lactate

Also Known As:

MSI-1256F

Networked: 4 relevant articles (0 outcomes, 4 trials/studies)

Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- Fused-Ring Compounds
  - Steroids: 70059
    - Cholestanes
      - Cholestanols: 67
        squalamine lactate: 4
Organic Chemicals: 133
- Carboxylic Acids: 973
  - Hydroxy Acids: 94
    - Lactates: 140
      - squalamine lactate: 4

Experts

1.	Desai, Avinash: 2 articles (09/2006 - 09/2003)
2.	Holroyd, Kenneth J: 2 articles (12/2003 - 09/2003)
3.	Williams, Jon I: 2 articles (12/2003 - 09/2003)
4.	Connolly, Brian: 1 article (09/2006)
5.	Garcia, Charles A: 1 article (09/2006)
6.	Gast, Michael J: 1 article (09/2006)
7.	Thomas, Edgar: 1 article (09/2006)
8.	Ciulla, Thomas A: 1 article (12/2003)
9.	Criswell, Mark H: 1 article (12/2003)
10.	Danis, Ronald P: 1 article (12/2003)

Related Diseases

1.	Neoplasms (Cancer) 09/01/2006 - "A series of basic investigations, preclinical studies, and human clinical trials have begun to establish the proof of concept, efficacy, and safety parameters for use of squalamine lactate as a therapeutic agent for exudative age-related macular degeneration and several types of malignancies." 12/01/2001 - "A Phase I study of squalamine, a novel antiangiogenic agent originally isolated from the dogfish shark Squalus acanthias, was conducted in patients with advanced cancers to: (a) determine the maximum tolerated dose (MTD), dose-limiting toxicity (DLT) and pharmacokinetics of squalamine lactate when given as a 120-h continuous i.v. infusion every two weeks; and (b) to obtain information on prolonged (>120-h) continuous i.v. infusions in patients who have tolerated 120-h infusions. "
2.	Macular Degeneration (Age-Related Maculopathy) 09/01/2006 - "Squalamine lactate for exudative age-related macular degeneration." 09/01/2006 - "A series of basic investigations, preclinical studies, and human clinical trials have begun to establish the proof of concept, efficacy, and safety parameters for use of squalamine lactate as a therapeutic agent for exudative age-related macular degeneration and several types of malignancies."
3.	Eye Diseases (Eye Disease) 12/01/2003 - "Further study of squalamine lactate for treatment of neovascular eye disease is warranted."
4.	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 09/15/2003 - "A phase I/IIA trial of continuous five-day infusion of squalamine lactate (MSI-1256F) plus carboplatin and paclitaxel in patients with advanced non-small cell lung cancer."
5.	Choroidal Neovascularization 12/01/2003 - "Squalamine lactate reduces choroidal neovascularization in a laser-injury model in the rat." 12/01/2003 - "To determine if systemically administered squalamine lactate, a novel aminosterol with antineoplastic and antiangiogenic activity, inhibits the development of experimental choroidal neovascularization membranes (CNVMs) induced by laser trauma in a rat model. "

Related Drugs and Biologics

1.	Angiogenesis Inhibitors
2.	Paclitaxel (Taxol)
3.	Carboplatin (JM8)
4.	squalamine
5.	Antineoplastic Agents (Antineoplastics)

Related Therapies and Procedures

1.	Lasers (Laser)