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AM1172

structure in first source

Also Known As:

N-(5Z,8Z,11Z,14Z-eicosatetraenyl)-4-hydroxybenzamide

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Fegley, D: 1 article (06/2004)
2.	Goutopoulos, A: 1 article (06/2004)
3.	Kathuria, S: 1 article (06/2004)
4.	Li, C: 1 article (06/2004)
5.	Makriyannis, A: 1 article (06/2004)
6.	Mercier, R: 1 article (06/2004)
7.	Piomelli, D: 1 article (06/2004)

Related Diseases

1.	Melanoma (Melanoma, Malignant) 11/29/2023 - "AM1172 cannot be used separately as a chemotherapeutic drug, but it can be combined with PACX, DOCX, MTX, and CDDP, offering additive interactions in terms of the anti-proliferative effects in various malignant melanoma cell lines." 11/29/2023 - "The isobolographic analysis revealed that combinations of AM1172 with PACX, DOCX, MTX, and CDDP exerted additive interactions, except for a combination of AM1172 with PACX in primary melanoma A375 cell line, for which synergy was observed (*p<0.05). " 11/29/2023 - "AM1172 (a hydrolysis-resistant endocannabinoid analog that inhibits anandamide cellular uptake) reduces the viability of the various melanoma cells, but it exerts significant cytotoxic effects on healthy cells: an in vitro study based on isobolographic analysis." 11/29/2023 - "This study was designed to assess the anti-proliferative and cytotoxic effects of AM1172 (a hydrolysis-resistant endocannabinoid analog that inhibits anandamide cellular uptake) administered alone and in combinations with docetaxel (DOCX), paclitaxel (PACX), mitoxantrone (MTX) and cisplatin (CDDP) on various human malignant melanoma A375, FM55P, SK-MEL 28 and FM55M2 cell lines. "
2.	Astrocytoma (Pilocytic Astrocytoma) 06/08/2004 - "In further support of this conclusion, the compound N-(5Z, 8Z, 11Z, 14Z eicosatetraenyl)-4-hydroxybenzamide (AM1172) blocked [(3)H]anandamide internalization in rodent cortical neurons and human astrocytoma cells without acting as a FAAH substrate or inhibitor. "

Related Drugs and Biologics

1.	anandamide (arachidonylethanolamide)
2.	Endocannabinoids
3.	Paclitaxel (Taxol)
4.	Mitoxantrone (Novantrone)
5.	Cisplatin (Platino)
6.	Docetaxel (Taxotere)