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PRA-910

structure in first source

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - PRA-910: 1
Organic Chemicals: 133
- Nitriles: 227
  - PRA-910: 1

Experts

1.	Berrodin, T J: 1 article (01/2007)
2.	Bretz, J: 1 article (01/2007)
3.	Chippari, S: 1 article (01/2007)
4.	Cohen, J: 1 article (01/2007)
5.	Fensome, A: 1 article (01/2007)
6.	Lundeen, S G: 1 article (01/2007)
7.	Slayden, O: 1 article (01/2007)
8.	Winneker, R C: 1 article (01/2007)
9.	Wrobel, J: 1 article (01/2007)
10.	Yudt, M R: 1 article (01/2007)

Related Diseases

1.

Breast Neoplasms (Breast Cancer)

01/01/2007 - "In a PR/PRE reporter assay in COS-7 cells, PRA-910 shows potent PR antagonist activity with an IC50 value of approximately 20 nM. In the alkaline phosphatase assay in the human breast cancer cell line T47D, PRA-910 is a partial progesterone antagonist at low concentrations and is also an effective PR agonist at higher concentrations (EC50 value of approximately 700 nM). "

Related Drugs and Biologics

1.	Progesterone
2.	Alkaline Phosphatase