|1.||Wang, Wen: 6 articles (09/2014 - 02/2008)|
|2.||Zhang, Li: 4 articles (09/2014 - 06/2009)|
|3.||Yokozawa, Takako: 4 articles (01/2011 - 07/2008)|
|4.||Park, Chan Hum: 4 articles (01/2011 - 07/2008)|
|5.||Tanaka, Takashi: 4 articles (01/2011 - 07/2008)|
|6.||Li, Lin: 4 articles (10/2010 - 02/2008)|
|7.||Ai, Hou-Xi: 3 articles (09/2014 - 09/2008)|
|8.||Noh, Jeong Sook: 3 articles (01/2011 - 10/2009)|
|9.||Ai, Houxi: 3 articles (10/2010 - 02/2008)|
|10.||An, Yi: 3 articles (06/2009 - 02/2008)|
07/01/2008 - "This suggests that morroniside exhibits protective effects against diabetic renal damage by inhibiting hyperglycemia and oxidative stress. "
10/01/2009 - "The generations of hepatic thiobarbituric acid-reactive substances and reactive oxygen species induced by hyperglycemia and dyslipidemia were also significantly decreased by the administration of morroniside. "
08/01/2010 - "These findings led us to conclude that morroniside, loganin, and 7-O-galloyl-D-sedoheptulose would synergistically contribute to the inhibition of metabolic disorders (hyperglycemia and dyslipidemia), oxidative stress, inflammation, as well as AGE formation in the diabetic kidney."
10/30/2010 - "The treatment with morroniside significantly improved Zea-Longa scores and Prehensile Traction score at the doses of 30, 90 and 270mg/kg, increased Ludmila Belayer score and reduced the infarction volume at the doses of 90 and 270mg/kg. Morroniside (30, 90 and 270mg/kg) treatment significantly decreased the level of malondialdehyde and caspase-3 activity by colorimetric analysis in ischemic cortex tissues. "
09/05/2014 - "Morroniside significantly promoted neurogenesis for brain recovery 7 days post-ischemia. "
09/05/2014 - "Morroniside was administered intragastrically once daily at the concentrations of 30, 90 and 270 mg/kg for 7 days post-ischemia. "
01/01/2014 - "Morever, the increase in the amount of vWF+ vessels induced by ischemia could be extended to 28 days after administration of morroniside, indicating the crucial role of morroniside in angiogenesis during the chronic phase. "
01/01/2014 - "By 7 days post-ischemia, morroniside amplified angiogenesis, in part by enhancing endothelial progenitor cell proliferation and expression of angiogenic factors. "
01/01/2014 - "We demonstrated that at 3 days post-ischemia, morroniside preserved neurovascular unit function by ameliorating BBB injury. "
01/01/2011 - "The present study was conducted to examine whether morroniside has an ameliorative effect on diabetes-induced alterations such as oxidative stress, inflammation, and apoptosis in the liver of type 2 diabetic db/db mice. "
01/01/2011 - "Taking these into consideration, our findings support the therapeutic evidence for morroniside ameliorating the development of diabetic hepatic complications via regulating oxidative stress, inflammation, and apoptosis."
01/01/2011 - "Evaluation of morroniside, iridoid glycoside from Corni Fructus, on diabetes-induced alterations such as oxidative stress, inflammation, and apoptosis in the liver of type 2 diabetic db/db mice."
03/01/2010 - "Morroniside may inhibit abnormal lipid metabolism and inflammation due to reactive oxygen species in the kidneys in type 2 diabetes."
03/01/2010 - "The effects of morroniside isolated from Corni Fructus on renal lipids and inflammation provoked by hyperglycaemia were investigated using type 2 diabetic mice. "
|5.||Brain Ischemia (Cerebral Ischemia)
09/05/2014 - "The aim of the present study is to test whether morroniside promotes neurogenesis via Wnt/β-catenin signaling pathway for brain recovery in a rat model of focal cerebral ischemia. "
09/05/2014 - "Promoting neurogenesis via Wnt/β-catenin signaling pathway accounts for the neurorestorative effects of morroniside against cerebral ischemia injury."
01/01/2014 - "Here, we considered alterations in microvessel integrity to be targets for brain recovery, and tested the natural compound morroniside as a therapeutic approach to restore the vascular elements of injured tissue in a rat model of focal cerebral ischemia. "
01/01/2014 - "Morroniside improves microvascular functional integrity of the neurovascular unit after cerebral ischemia."
10/30/2010 - "These findings demonstrated that morroniside could notably protect the brain from damage induced by focal cerebral ischemia which might be related to morroniside antioxidant and anti-apoptotic properties in the brain."
|1.||Caspase 3 (Caspase-3)
|5.||Reactive Oxygen Species (Oxygen Radicals)
|7.||Proto-Oncogene Proteins c-akt (Protein Kinase B)
|8.||Thiobarbituric Acid Reactive Substances