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thioretinaco

protective agent against atherogenesis induced by homocysteine thiolactone; structure in first source
Networked: 13 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1. McCully, Kilmer S: 11 articles (09/2020 - 01/2015)

Related Diseases

1. Atherosclerosis
2. Mitochondrial Diseases (Mitochondrial Disease)
3. Dementia (Dementias)
01/01/2018 - "Communication: Melatonin, Hyperhomocysteinemia, Thioretinaco Ozonide, Adenosylmethionine and Mitochondrial Dysfunction in Aging and Dementia."
01/01/2018 - "According to this analysis, the critical loss of thioretinaco ozonide from mitochondria through the opening of the permeability transition pore and disruption of the outer mitochondrial membrane by decreased melatonin secretion leads to the impaired oxidative phosphorylation, oxidative stress, calcium influx, apoptosis and mitochondrial dysfunction observed in aging and dementia."
05/01/2018 - "Thus the loss of thioretinaco ozonide from mitochondria produces the impaired oxidative phosphorylation, oxidative stress, calcium influx, apoptosis, aerobic glycolysis, and mitochondrial dysfunction that are observed in chemical carcinogenesis, microbial carcinogenesis, traumatic brain injury, aging and dementia."
01/01/2017 - "The down-regulation of oxidative phosphorylation that is observed in aging and dementia is attributed to deficiency of thioretinaco ozonide oxygen complexed with nicotinamide adenine dinucleotide and phosphate, which catalyzes oxidative phosphorylation. "
01/01/2015 - "The hyperhomocysteinemia of aging and dementia is attributed to decreased synthesis of adenosyl methionine by thioretinaco ozonide and ATP, causing decreased allosteric activation of cystathionine synthase and decreased allosteric inhibition of methylenetetrahydrofolate reductase and resulting in dysregulation of methionine metabolism."
4. Carcinogenesis
5. Hyperhomocysteinemia

Related Drugs and Biologics

1. Homocysteine
2. N-homocysteine thiolactonyl retinamide
3. homocysteine thiolactone
4. N-homocysteine thiolactonyl retinamido cobalamin
5. 1,2,4-trioxane
6. Oxygen (Dioxygen)
7. Adenosine Triphosphate (ATP)
8. Methionine (L-Methionine)
9. Mitochondrial Permeability Transition Pore
10. Vitamin B 12 (Cyanocobalamin)