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Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results


1. Hazuda, Daria J: 2 articles (01/2014 - 07/2004)
2. Lifson, Jeffrey D: 1 article (01/2014)
3. Ling, Binhua: 1 article (01/2014)
4. Veazey, Ronald S: 1 article (01/2014)
5. Russell-Lodrigue, Kasi: 1 article (01/2014)
6. Johnson, Ann-Marie: 1 article (01/2014)
7. Piatak, Michael: 1 article (01/2014)
8. Rogers, Linda: 1 article (01/2014)
9. Di Santo, Roberto: 1 article (07/2008)
10. Van Herrewege, Yven: 1 article (07/2008)

Related Diseases

1. Infection
07/01/2008 - "Furthermore, the addition of micromolar concentrations of L-870812 even 24 h after infection could still block both cell-free and cell-associated Ba-L, opening the prospect of postexposure prophylaxis. "
07/23/2004 - "L-870812 was also active in chronic infection; however, the magnitude and durability of the effect varied in conjunction with the pretreatment immune response and viral load. "
07/01/2008 - "Using cocultures of monocyte-derived dendritic cells and CD4(+) T cells, which represent primary targets in sexual transmission, we demonstrated that blocking integration with integrase strand transfer inhibitors (InSTIs), particularly L-870812, could consistently block cell-free and cell-associated HIV-1 infection. "
01/01/2014 - "SIVmac251 infected Ch-RM received reverse transcriptase inhibitors PMPA and FTC and integrase inhibitor L-870812 beginning 7 weeks post infection. "
07/01/2008 - "In a pretreatment setting in which the compound was present before and during infection and was afterwards gradually diluted during the culture period, the naphthyridine carboxamide L-870812 blocked infection with the cell-free and cell-associated HIV-1 Ba-L strain at concentrations of, respectively, 1,000 and 10,000 nM. The potency of L-870812 was similar to that of the nucleotide reverse transcriptase inhibitor R-9-(2-phosphonylmethoxypropyl) adenine (PMPA) but one or two orders of magnitude lower than those of the nonnucleoside reverse transcriptase inhibitors UC781 and TMC120. "
2. Viremia

Related Drugs and Biologics

1. Integrases
2. Reverse Transcriptase Inhibitors
3. pinacolyl methylphosphonic acid
4. RNA-Directed DNA Polymerase (Reverse Transcriptase)
5. Adenine
6. UC 781