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2,5- bis(4- hydroxy- 3- methoxybenzylidene)cyclopentanone

has antineoplastic activity; structure in first source

Also Known As:

BPR0Y007

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Ketones: 2618
  - Pentanones
    - 2,5-bis(4-hydroxy-3-methoxybenzylidene)cyclopentanone: 2
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Benzylidene Compounds: 10
        2,5-bis(4-hydroxy-3-methoxybenzylidene)cyclopentanone: 2

Experts

1.	Chang, Jang-Yang: 2 articles (07/2004 - 06/2003)
2.	Chen, Li-Tzong: 2 articles (07/2004 - 06/2003)
3.	Hsieh, Hsing-Pang: 2 articles (07/2004 - 06/2003)
4.	Liou, Jing-Ping: 2 articles (07/2004 - 06/2003)
5.	Pan, Wen-Yu: 2 articles (07/2004 - 06/2003)
6.	Hung, Yi-Mei: 1 article (07/2004)
7.	Juang, Shin-Hun: 1 article (07/2004)
8.	Kuo, Ching-Chuan: 1 article (07/2004)
9.	Bey, Shian-Jy: 1 article (06/2003)
10.	Liu, Jin-Fen: 1 article (06/2003)

Related Diseases

1.	Neoplasms (Cancer) 06/15/2003 - "The IC(50) of BPR0Y007 for various human cancer cell lines ranged from 1 to 8 microM. " 07/15/2004 - "BPR0Y007, a bis-benzylidenecyclopentanone derivative (2,5-bis- (4-hydroxy-3-methoxybenzylidene) cyclopentanone), was identified in our laboratory as a novel antineoplastic agent with a broad spectrum of antitumor activity against many human cancer cells. "
2.	Squamous Cell Carcinoma (Epidermoid Carcinoma) 07/15/2004 - "A novel bis-benzylidenecyclopentanone derivative, BPR0Y007, inducing a rapid caspase activation involving upregulation of Fas (CD95/APO-1) and wild-type p53 in human oral epidermoid carcinoma cells."

Related Drugs and Biologics

1.	Caspases
2.	Antineoplastic Agents (Antineoplastics)