2-(acetyloxy)benzoic acid 6-(nitrooxymethyl)-2-phenylmethyl ester (NO-ibuprofen)

Also Known As:

NO-ibuprofen; NCX 4060; NCX-4060; NCX4060

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Nitrates: 6625
  - 2-(acetyloxy)benzoic acid 6-(nitrooxymethyl)-2-phenylmethyl ester: 4
- Carboxylic Acids: 973
  - Carbocyclic Acids
    - Phenylpropionates
      - Ibuprofen: 5288
        2-(acetyloxy)benzoic acid 6-(nitrooxymethyl)-2-phenylmethyl ester: 4
Inorganic Chemicals: 9
- Electrolytes: 16106
  - Ions: 7857
    - Anions: 3501
      - Nitrates: 6625
        2-(acetyloxy)benzoic acid 6-(nitrooxymethyl)-2-phenylmethyl ester: 4
- Nitrogen Compounds: 67
  - Nitric Acid: 155
    - Nitrates: 6625
      - 2-(acetyloxy)benzoic acid 6-(nitrooxymethyl)-2-phenylmethyl ester: 4

Experts

1.	Ansell, Ian: 1 article (07/2004)
2.	Bollina, Prasad: 1 article (07/2004)
3.	Habib, Fouad K: 1 article (07/2004)
4.	Ross, James A: 1 article (07/2004)
5.	Royle, Justine Sarah: 1 article (07/2004)
6.	Tulloch, David N: 1 article (07/2004)
7.	Borgo, S: 1 article (04/2001)
8.	Castillo, E: 1 article (04/2001)
9.	Hasan, I: 1 article (04/2001)
10.	Rigas, B: 1 article (04/2001)

Related Diseases

1.	Prostatic Neoplasms (Prostate Cancer) 07/01/2004 - "We studied the effects of NO-ibuprofen (NCX 2111) and NO-aspirin (NCX 4060) on hormone sensitive (LNCap) and insensitive (PC3) prostate cancer epithelial cell lines as well as primary cultures of prostatic stroma. "
2.	Periapical Periodontitis (Apical Periodontitis) 12/01/2022 - "Ninety patients with symptomatic apical periodontitis scheduled to undergo endodontic therapy were randomised to receive either local ibuprofen, systemic ibuprofen, or no ibuprofen (control). "
3.	Neoplasms (Cancer) 01/01/1997 - "Addition of both prostaglandin E2 and ibuprofen to the culture medium restored tumor cell invasiveness through Matrigel-coated membranes to levels nearly identical to vehicle exposed controls (DMSO-no ibuprofen). "
4.	Colonic Neoplasms (Colon Cancer) 04/15/2001 - "Nitric oxide-releasing nonsteroidal anti-inflammatory drugs (NO-NSAIDs), consisting of a known nonsteroidal anti-inflammatory drug (NSAID) and a nitric oxide (NO)-releasing group, are reported safer than NSAIDS: To assess their potential in colon cancer chemoprevention, we studied in vitro the effect of NO-aspirin, NO-sulindac, and NO-ibuprofen on colonocyte kinetics. " 04/15/2001 - "These three NO-NSAIDs reduced the growth of cultured HT-29 colon adenocarcinoma cells much more effectively than the corresponding NSAIDs; e.g., at 24 h, their IC(50) values were as follows: (a) aspirin, >5000 microM; (b) NO-aspirin, 1 microM; (c) sulindac, 750 microM; (d) NO-sulindac, 150 microM; (e) ibuprofen, >1000 microM; and (f) NO-ibuprofen, 42 microM. "

Related Drugs and Biologics

1.	Ibuprofen (Motrin)
2.	N- acetyl- S- (alpha- methyl- 4- (2- methylpropyl)benzeneacetyl)cysteine 4-(nitrooxy)butyl ester
3.	2-(acetyloxy)benzoic acid 6-(nitrooxymethyl)-2-phenylmethyl ester (NO-ibuprofen)
4.	Dinoprostone (PGE2)
5.	Sulindac (Copal)
6.	Nitric Oxide (Nitrogen Monoxide)
7.	Hormones (Hormone)
8.	Dimethyl Sulfoxide (DMSO)
9.	Aspirin (Acetylsalicylic Acid)
10.	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)

Related Therapies and Procedures

1.	Chemoprevention
2.	Therapeutics