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carbamylated erythropoietin

has neuroprotective activity without erythropoietic activity
Networked: 25 relevant articles (4 outcomes, 2 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Takahara, Shiro: 4 articles (12/2012 - 02/2007)
2. Imamura, Ryoichi: 4 articles (12/2012 - 02/2007)
3. Ichimaru, Naotsugu: 4 articles (12/2012 - 02/2007)
4. Isaka, Yoshitaka: 4 articles (12/2012 - 02/2007)
5. Vcelar, Brigitta: 3 articles (03/2013 - 09/2011)
6. Okumi, Masayoshi: 3 articles (12/2012 - 01/2008)
7. Nonomura, Norio: 3 articles (12/2012 - 01/2008)
8. Okuyama, Akihiko: 3 articles (01/2012 - 02/2007)
9. Brines, Michael: 3 articles (11/2006 - 04/2006)
10. Schelzig, Hubert: 2 articles (03/2013 - 09/2011)

Related Diseases

1. Anoxia (Hypoxia)
2. Brain Injuries (Brain Injury)
3. Brain Edema (Cerebral Edema)
09/01/2011 - "Our findings indicate that early posttraumatic administration of carbamylated erythropoietin reduces brain edema development until at least 6 hrs postinjury and improves neurologic recovery. "
09/01/2011 - "Reduced brain edema and functional deficits after treatment of diffuse traumatic brain injury by carbamylated erythropoietin derivative."
09/01/2011 - "Compared to traumatic brain injury-saline rats, rats receiving traumatic brain injury-carbamylated erythropoietin showed a significant reduction in brain edema formation at 1 hr that was sustained until 6 hrs when results were comparable with sham-operated rats. "
09/01/2011 - "Three series of experiments were conducted to investigate: 1) the effect of carbamylated erythropoietin on brain edema before and 1 hr after traumatic brain injury using diffusion-weighted magnetic resonance imaging and measurements of apparent diffusion coefficient (n = 10 rats per group), and the phosphorylation level of brain extracellular-regulated kinase-1/-2 was also determined to indicate the presence of an activated cell signaling pathway; 2) the time course of brain edema using magnetic resonance imaging between 4 and 6 hrs postinjury and the gravimetric technique at 6 hrs (n = 10 rats per group); and 3) motor and cognitive function over 10 days post traumatic brain injury, testing acute somatomotor reflexes, adhesive paper removal, and two-way active avoidance (n = 8 rats per group). "
09/01/2011 - "To investigate the effects of carbamylated erythropoietin, a modified erythropoietin lacking erythropoietic activity, on brain edema and functional recovery in a model of diffuse traumatic brain injury. "
4. Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease)
5. Parkinson Disease (Parkinson's Disease)

Related Drugs and Biologics

1. Erythropoietin
2. Choline O-Acetyltransferase (Choline Acetyltransferase)
3. salicylhydroxamic acid (SHAM)
4. Recombinant Erythropoietin
5. Sodium Chloride (Saline Solution)
6. Phosphotransferases (Kinase)
7. Hemoglobins (Hemoglobin)
8. darbepoetin alfa (Aranesp)

Related Therapies and Procedures

1. Aftercare (After-Treatment)
2. Balloon Occlusion
3. Transplants (Transplant)