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Mana-Hox

an analog of manzamine alkaloids, which are beta-carboline alkaloids isolated from marine sponges

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - Carbolines: 283
      - Mana-Hox: 1
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - Indole Alkaloids: 200
        Carbolines: 283
        Mana-Hox: 1
  - 3-Ring Heterocyclic Compounds
    - Carbolines: 283
      - Mana-Hox: 1

Experts

1.	Chang, Wei-Ling: 1 article (12/2008)
2.	Chen, Yi-Cheng: 1 article (12/2008)
3.	Guh, Jih-Hwa: 1 article (12/2008)
4.	Ho, Yunn-Fang: 1 article (12/2008)
5.	Hsiao, Che-Jen: 1 article (12/2008)
6.	Hsu, John T-A: 1 article (12/2008)
7.	Lyu, Ping-Chiang: 1 article (12/2008)
8.	Shen, Ya-Ching: 1 article (12/2008)

Related Diseases

1.	Colorectal Neoplasms (Colorectal Cancer) 12/01/2008 - "In this study, Mana-Hox induced an inhibition of cell proliferation in several types of human cancer cell lines, including androgen-independent prostate cancer PC-3 and DU-145, hepatocellular carcinoma Hep3B and HepG2, and colorectal cancer HT-29 cells. "
2.	Prostatic Neoplasms (Prostate Cancer) 12/01/2008 - "Mana-Hox displays anticancer activity against prostate cancer cells through tubulin depolymerization and DNA damage stress." 12/01/2008 - "In this study, Mana-Hox induced an inhibition of cell proliferation in several types of human cancer cell lines, including androgen-independent prostate cancer PC-3 and DU-145, hepatocellular carcinoma Hep3B and HepG2, and colorectal cancer HT-29 cells. "
3.	Neoplasms (Cancer) 12/01/2008 - "Notably, Mana-Hox was not a P-glycoprotein (P-gp) substrate and showed equipotent activity against P-gp-rich cancer cells. " 12/01/2008 - "In this study, Mana-Hox induced an inhibition of cell proliferation in several types of human cancer cell lines, including androgen-independent prostate cancer PC-3 and DU-145, hepatocellular carcinoma Hep3B and HepG2, and colorectal cancer HT-29 cells. "
4.	Hepatocellular Carcinoma (Hepatoma) 12/01/2008 - "In this study, Mana-Hox induced an inhibition of cell proliferation in several types of human cancer cell lines, including androgen-independent prostate cancer PC-3 and DU-145, hepatocellular carcinoma Hep3B and HepG2, and colorectal cancer HT-29 cells. "
5.	Ataxia Telangiectasia (Louis Bar Syndrome) 12/01/2008 - "Mana-Hox stimulated an increase of ataxia telangiectasia mutated (ATM) phosphorylation on Ser-1981, indicating the induction of DNA double-strand breaks. "

Related Drugs and Biologics

1.	Androgens
2.	Member 1 Subfamily B ATP Binding Cassette Transporter
3.	Tubulin
4.	DNA (Deoxyribonucleic Acid)