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Leu-Ser-Lys-Leu peptide

Also Known As:

LSKL peptide; leucyl-seryl-lysyl-leucyl peptide

Networked: 6 relevant articles (2 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Leu-Ser-Lys-Leu peptide: 6

Experts

1.	Gao, Yashan: 1 article (04/2020)
2.	Gu, Shuchen: 1 article (04/2020)
3.	Gu, Yi-Hui: 1 article (04/2020)
4.	Huang, Xin: 1 article (04/2020)
5.	Khoong, Yi Min: 1 article (04/2020)
6.	Li, Haizhou: 1 article (04/2020)
7.	Ren, Jie-Yi: 1 article (04/2020)
8.	Wang, Zhichao: 1 article (04/2020)
9.	Xu, Xiangwen: 1 article (04/2020)
10.	Zan, Tao: 1 article (04/2020)

Related Diseases

1.	Seizures (Absence Seizure) 03/01/2020 - "Inhibition of TSP-1 expression by small interfering RNA or inhibition of TGF-β1 activation with a Leu-Ser-Lys-Leu peptide significantly reduced the severity of KA-induced acute seizures. "
2.	Proteinuria 06/01/2011 - "Proteinuria (urinary albumin level and albumin/creatinine ratio) was significantly improved in Akita mice treated with 30 mg/kg LSKL peptide. "
3.	Fibrosis (Cirrhosis) 10/01/2016 - "In conclusion, the LSKL peptide suppresses subarachnoid fibrosis via inhibition of TSP1-mediated TGF-β1 activity, prevents the development of chronic hydrocephalus and improves long-term neurocognitive defects following SAH." 11/01/2003 - "The LSKL peptide prevented the progression of hepatic damage and fibrosis through the inhibition of TGF-beta1 activation and its signal transduction in vivo." 10/01/2016 - "LSKL peptide alleviates subarachnoid fibrosis and hydrocephalus by inhibiting TSP1-mediated TGF-β1 signaling activity following subarachnoid hemorrhage in rats." 10/01/2016 - "To investigate whether LSKL peptide, a small molecular peptide and competitive antagonist for TGF-β1, protects against subarachnoid fibrosis and hydrocephalus after SAH, a two-hemorrhage injection model of SAH was created in Sprague-Dawley rats. "
4.	Atherosclerosis 02/01/2015 - "Administration of LSKL peptide promoted larger suprarenal aortic diameter, as determined by ultrasound and morphometric analysis, and stimulated more severe atherosclerosis within the aortic arch. "
5.	Hypertrophic Cicatrix (Hypertrophic Scar) 04/01/2020 - "Investigating the potential of LSKL peptide as a novel hypertrophic scar treatment."

Related Drugs and Biologics

1.	Small Interfering RNA (siRNA)
2.	Thrombospondin 1
3.	Creatinine
4.	Albumins
5.	Transforming Growth Factor beta1 (TGF beta 1)
6.	Peptides (Polypeptides)