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neuroprotectin D1

a docosahexaenoic acid-derived docosatriene protects human retinal pigment epithelial cells from oxidative stress; structure in first source
Also Known As:
10R,17S-dihydroxy-docosa-4Z,7Z,11E,13E,15Z,19Z-hexaenoic acid; protectin D1
Networked: 43 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Bazan, Nicolas G: 17 articles (11/2015 - 04/2005)
2. Serhan, Charles N: 10 articles (09/2013 - 10/2005)
3. Petasis, Nicos A: 5 articles (01/2015 - 02/2006)
4. Hong, Song: 4 articles (07/2012 - 02/2006)
5. Levy, Bruce D: 3 articles (03/2015 - 01/2007)
6. Arita, Makoto: 3 articles (03/2013 - 06/2007)
7. Lu, Yan: 3 articles (07/2012 - 02/2006)
8. Lukiw, Walter J: 3 articles (01/2011 - 10/2005)
9. Marcheselli, Victor L: 3 articles (08/2007 - 08/2005)
10. Gotlinger, Katherine: 3 articles (01/2007 - 10/2005)

Related Diseases

1. Inflammation
01/01/2014 - "Protectin D1 (PD1), derived from docosahexaenoic acid, has been shown to control and resolve inflammation in some experimental models of inflammatory disorders. "
10/01/2011 - "Specifically in the epididymal fat in the abdomen, but not in other fat depots, synergistic induction of mitochondrial oxidative capacity and lipid catabolism was observed, resulting in increased oxidation of metabolic fuels in the absence of mitochondrial uncoupling, while low-grade inflammation was suppressed, reflecting changes in tissue levels of anti-inflammatory lipid mediators, namely 15-deoxy-Δ(12,15)-prostaglandin J(2) and protectin D1. "
08/01/2010 - "This review will focus on the roles of stress genes, apoptosis-related genes, and inflammation in the molecular genetics of AD with emphasis on the interactive nature of inflammatory, neurotrophic, and apoptotic signaling and will highlight areas of rapid progress in the characterization of action of DHA and neuroprotectin D1 and address important research challenges. "
11/01/2006 - "Omega-3 fatty acid docosahexaenoic acid is converted to potent resolvins (Rv) and protectin D1 (PD1), two newly identified families of natural mediators of resolution of inflammation. "
01/01/2007 - "In this study, we provide the first evidence for protectin D1 (PD1, 10R,17S-dihydroxy-docosa-4Z,7Z,11E,13E,15Z,19Z-hexaenoic acid) formation from docosahexaenoic acid in human asthma in vivo and PD1 counterregulatory actions in allergic airway inflammation. "
2. Asthma (Bronchial Asthma)
3. Atherosclerosis
4. Stroke (Strokes)
5. Alzheimer Disease (Alzheimer's Disease)

Related Drugs and Biologics

1. neuroprotectin D1
2. 5S,12R,18R- trihydroxy- 6Z,8E,10E,14Z,16E- eicosapentaenoic acid
3. Omega-3 Fatty Acids (Omega 3 Fatty Acids)
4. Leukotrienes
5. Lipoxygenase (Lipoxygenase-1)
6. resolvin D1
7. Lipoxins
8. Retinaldehyde (Retinal)
9. Docosahexaenoic Acids
10. lipoxin A4

Related Therapies and Procedures

1. Lasers (Laser)
2. Refractive Surgical Procedures