maesabalide III

isolated from the Vietnamese plant Maesa balansae; structure in first source

Networked: 2 relevant articles (1 outcomes, 0 trials/studies)

1.	Leishmaniasis 01/13/2005 - "Maesabalide III (3) and IV (4) were the most potent with IC(50) values against intracellular amastigotes of about 7 and 14 ng/mL. In comparison, the IC(50) value of sodium stibogluconate, the reference drug for treatment of leishmaniasis, is only 5.6 microg/mL. No cytotoxicity was present on a human fibroblast (MRC-5) cell line (CC(50) > 32 microg/mL). "
2.	Infections 06/01/2004 - "Maesabalide III (MB-III), an oleane triterpene saponin isolated from the Vietnamese plant Maesa balansae, is a new antileishmanial lead compound whose activity against Leishmania donovani (MHOM/ET/67/L82) in groups of five golden hamsters was evaluated after administration of a single subcutaneous dose on either day 1 (prophylactic treatment) or day 28 (curative treatment) after infection. "

1.	Antimony Sodium Gluconate (Sodium, Stibogluconate)
2.	Triterpenes
3.	Saponins