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TG 003

a Clk inhibitor; structure in first source

Also Known As:

TG-003; TG003; TG003 cpd

Networked: 6 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Sulfur Compounds: 278
  - Thiazoles: 392
    - TG 003: 6
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Thiazoles: 392
      - TG 003: 6

Experts

1.	Hagiwara, Masatoshi: 3 articles (12/2021 - 03/2014)
2.	Iida, Kei: 2 articles (12/2021 - 09/2015)
3.	Uzor, Simon: 2 articles (12/2021 - 09/2018)
4.	Ajiro, Masahiko: 1 article (12/2021)
5.	Alqasem, Abdullah A: 1 article (12/2021)
6.	Clark, Bethany: 1 article (12/2021)
7.	Ladomery, Michael R: 1 article (12/2021)
8.	Li, Ling: 1 article (12/2021)
9.	Oltean, Sebastian: 1 article (12/2021)
10.	Perks, Claire M: 1 article (12/2021)

Related Diseases

1.	Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker) 09/24/2015 - "In this study, we chose TG003, a potential drug for Duchenne muscular dystrophy, and performed RNA-sequencing on samples from human and mouse skeletal muscle cells, with and without TG003 treatments. "
2.	Neoplasms (Cancer) 09/05/2018 - "CLK1 inhibition with TG003 also resulted in modified alternative splicing of five cancer-associated genes." 09/01/2014 - "In addition to the tumor suppressor p53 protein, also termed p53α, the TP53 gene produces p53β and p53γ through alternative splicing of exons 9β and 9γ located within TP53 intron 9. Here we report that both TG003, a specific inhibitor of Cdc2-like kinases (Clk) that regulates the alternative splicing pre-mRNA pathway, and knockdown of SFRS1 increase expression of endogenous p53β and p53γ at mRNA and protein levels. "
3.	Prostatic Neoplasms (Prostate Cancer) 12/01/2021 - "We measured the effect of the CLK inhibitor, the benzothiazole TG003, on two prostate cancer cell lines. "
4.	Hyperalgesia 03/10/2014 - "Intrathecal injection of either TG003 (1-100 pmol) or IC261 (0.1-1 nmol) dose-dependently decreased mechanical allodynia and thermal hyperalgesia induced by carrageenan or CFA. "
5.	Body Weight (Weight, Body) 01/01/2017 - "The reduction of CLK2 expression in the hypothalamus, by chronic pharmacological inhibition with TG003 or by chronic knockdown with small interfering RNA was sufficient to abolish the anorexigenic effect of insulin and leptin, to increase body weight, fat mass, food intake and to decrease energy expenditure in mice on chow. "

Related Drugs and Biologics

1.	RNA (Ribonucleic Acid)
2.	Small Interfering RNA (siRNA)
3.	Leptin
4.	Messenger RNA (mRNA)
5.	RNA Precursors (Precursor, mRNA)
6.	Proteins (Proteins, Gene)
7.	Phosphotransferases (Kinase)
8.	Insulin (Novolin)
9.	Carrageenan
10.	IC 261

Related Therapies and Procedures

1.	Spinal Injections