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2-(3-(4-(4-chlorophenyl)-1-piperazinyl) propyl)-4(3H)-quinazolinone

structure in first source

Also Known As:

FR255595

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Piperazines: 26
    - 2-(3-(4-(4-chlorophenyl)-1-piperazinyl) propyl)-4(3H)-quinazolinone: 1
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinazolines: 402
      - Quinazolinones: 124
        2-(3-(4-(4-chlorophenyl)-1-piperazinyl) propyl)-4(3H)-quinazolinone: 1

Experts

1.	Hattori, Kouji: 1 article (06/2004)
2.	Ishida, Junya: 1 article (06/2004)
3.	Iwashita, Akinori: 1 article (06/2004)
4.	Matsuoka, Nobuya: 1 article (06/2004)
5.	Mihara, Kayoko: 1 article (06/2004)
6.	Mutoh, Seitaro: 1 article (06/2004)
7.	Yamamoto, Hirofumi: 1 article (06/2004)
8.	Yamazaki, Syunji: 1 article (06/2004)

Related Diseases

1.	Neurodegenerative Diseases (Neurodegenerative Disease) 06/01/2004 - "These findings clearly indicate that the novel PARP-1 inhibitor FR255595 exerts neuroprotective effect through its potent PARP-1 inhibitory actions in PD model, suggesting that the drug could be an attractive candidate for several neurodegenerative disorders, including PD."
2.	Parkinson Disease (Parkinson's Disease) 06/01/2004 - "Here, we show that prevention of PARP activation by FR255595 protects against both ROS-induced cells injury in vitro and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced nigrostriatal dopaminergic damage in an in vivo Parkinson's disease (PD) model. " 06/01/2004 - "Neuroprotective effects of a novel poly(ADP-ribose) polymerase-1 inhibitor, 2-[3-[4-(4-chlorophenyl)-1-piperazinyl] propyl]-4(3H)-quinazolinone (FR255595), in an in vitro model of cell death and in mouse 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease."

Related Drugs and Biologics

1.	Quinazolinones
2.	Neuroprotective Agents
3.	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)
4.	Poly (ADP-Ribose) Polymerase-1