neoline

01/01/2021 - "Neoline is effective against neuropathic pain models, but the effects of neoline against AD-like phenotypes have not been investigated. "
06/20/2016 - "The present study indicates that PA and its active ingredient neoline are promising agents to alleviate L-OHP-induced neuropathic pain."
09/15/2019 - "Neoline can be used as a marker compound to determine the quality of the PA products for the treatment of neuropathic pain."
09/15/2019 - "The present results indicate that PA and its active ingredient, neoline, are promising agents for the alleviation of neuropathic pain. "
09/15/2019 - "Neoline is the active ingredient of processed aconite root against murine peripheral neuropathic pain model, and its pharmacokinetics in rats."

01/01/2023 - "Songorine (S), neoline, talatizamine, 8-gingerol (G) and isoliquiritigenin (I), exhibiting stronger retention on the first-dimension CMMC column, were screened to have protective effects against DOX cardiotoxicity in the H9c2 cell model. "

09/15/2020 - "These results suggest that neoline might be a novel active ingredient of GJG and PA that is one of responsible ingredients for ameliorating mechanical hyperalgesia in diabetes via the inhibition of Nav1.7 VGSC current at least."
06/20/2016 - "Moreover, subcutaneous injection of neoline attenuated cold and mechanical hyperalgesia in L-OHP-treated mice. "
09/15/2020 - "In the present study, we investigated whether GJG, PA, and neoline could inhibit Nav1.7 voltage-gated sodium channel (VGSC) current and whether neoline could ameliorate mechanical hyperalgesia in diabetic mice. "
09/15/2020 - "Neoline, an active ingredient of the processed aconite root in Goshajinkigan formulation, targets Nav1.7 to ameliorate mechanical hyperalgesia in diabetic mice."
09/15/2019 - "PA extract and neoline significantly attenuated the mechanical hyperalgesia induced by either paclitaxel or partial ligation of the sciatic nerve in mice. "

09/15/2019 - "In our previous study, PA and its active ingredient, neoline, alleviated oxaliplatin-induced peripheral neuropathy in mice. "

03/01/2021 - "Many studies have shown the beneficial effects of aconite water-soluble alkaloid extract (AWA) in experimental models of heart disease, which have been ascribed to the presence of aconine, hypaconine, talatisamine, fuziline, neoline, and songorine. "