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N- (2- (5- methoxy- 2- oxo- 2,3- dihydro- 1H- indol- 3- yl)ethyl)acetamide

metabolite of melatonin; structure in first source

Also Known As:

2-hydroxymelatonin

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - Tryptamines: 1679
        Melatonin: 11033
        N-(2-(5-methoxy-2-oxo-2,3-dihydro-1H-indol-3-yl)ethyl)acetamide: 1
Hormones, Hormone Substitutes, and Hormone Antagonists
- Hormones: 80400
  - Melatonin: 11033
    - N-(2-(5-methoxy-2-oxo-2,3-dihydro-1H-indol-3-yl)ethyl)acetamide: 1

Experts

1.	Back, Kyoungwhan: 1 article (03/2017)
2.	Bae, Woo Kyun: 1 article (03/2017)
3.	Kim, Hangun: 1 article (03/2017)
4.	Kim, Kyung Keun: 1 article (03/2017)
5.	Park, So-Yeon: 1 article (03/2017)
6.	Yang, Yi: 1 article (03/2017)
7.	Zhou, Rui: 1 article (03/2017)

Related Diseases

1.	Colorectal Neoplasms (Colorectal Cancer) 03/14/2017 - "Taken together, 2-hydroxymelatonin exhibits potent anti-cancer activity against human colorectal cancer cells via induction of apoptosis and inhibition of EMT." 03/14/2017 - "To investigate whether it has potent cytotoxic effects on colorectal cancer cells, four colorectal cancer cell lines, Caco2, HCT116, DLD1, and CT26, were treated with 2-hydroxymelatonin and melatonin. " 03/14/2017 - "2-Hydroxymelatonin, a Predominant Hydroxylated Melatonin Metabolite in Plants, Shows Antitumor Activity against Human Colorectal Cancer Cells."
2.	Neoplasms (Cancer) 03/14/2017 - "Taken together, 2-hydroxymelatonin exhibits potent anti-cancer activity against human colorectal cancer cells via induction of apoptosis and inhibition of EMT." 03/14/2017 - "Overall, the anti-cancer activity of 2-hydroxymelatonin is more potent than that of melatonin. "

Related Drugs and Biologics

1.	Melatonin