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1- (2- hydroxy- 4- morpholin- 4- ylphenyl)ethanone

a DNA-dependent protein kinase inhibitor

Also Known As:

IC 86621; IC-86621; IC86621

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Ketones: 2618
  - Acetophenones: 16
    - 1-(2-hydroxy-4-morpholin-4-ylphenyl)ethanone: 2
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Oxazines: 9
    - Morpholines: 6
      - 1-(2-hydroxy-4-morpholin-4-ylphenyl)ethanone: 2

Experts

1.	Gozaly-Chianea, Yaghoub: 1 article (03/2013)
2.	Slijepcevic, Predrag: 1 article (03/2013)
3.	Yasaei, Hemad: 1 article (03/2013)
4.	Aziz, Khaled: 1 article (05/2010)
5.	Bonner, William M: 1 article (05/2010)
6.	Burns, Kara J: 1 article (05/2010)
7.	Dickey, Jennifer S: 1 article (05/2010)
8.	Francisco, Dave C: 1 article (05/2010)
9.	Georgakilas, Alexandros G: 1 article (05/2010)
10.	Hair, Jessica M: 1 article (05/2010)

Related Diseases

1.	Lymphoma (Lymphomas) 03/22/2013 - "We demonstrate here that the IC86621 mediated inhibition of DNA-PKcs in two mouse lymphoma cell lines results not only in elevated frequencies of chromosome end-to-end fusions, but also accelerated telomere shortening in the presence of telomerase. "
2.	Glioblastoma (Glioblastoma Multiforme) 05/15/2010 - "To examine the role of DNA-PK in processing of non-DSB clustered DNA damage, we have used three models of DNA-PK deficiency, i.e., chemical inactivation of its kinase activity by the novel inhibitors IC86621 and NU7026, knockdown and complete absence of the protein in human breast cancer (MCF-7) and glioblastoma cell lines (MO59-J/K). "
3.	Breast Neoplasms (Breast Cancer) 05/15/2010 - "To examine the role of DNA-PK in processing of non-DSB clustered DNA damage, we have used three models of DNA-PK deficiency, i.e., chemical inactivation of its kinase activity by the novel inhibitors IC86621 and NU7026, knockdown and complete absence of the protein in human breast cancer (MCF-7) and glioblastoma cell lines (MO59-J/K). "
4.	Pyruvate Kinase Deficiency of Red Cells 05/15/2010 - "To examine the role of DNA-PK in processing of non-DSB clustered DNA damage, we have used three models of DNA-PK deficiency, i.e., chemical inactivation of its kinase activity by the novel inhibitors IC86621 and NU7026, knockdown and complete absence of the protein in human breast cancer (MCF-7) and glioblastoma cell lines (MO59-J/K). "

Related Drugs and Biologics

1.	DNA (Deoxyribonucleic Acid)
2.	Telomerase (Telomerase Reverse Transcriptase)
3.	Proteins (Proteins, Gene)
4.	Phosphotransferases (Kinase)
5.	2-(morpholin-4-yl)benzo(h)chromen-4-one
6.	lysyl- arginyl- alanyl- lysyl- alanyl- lysyl- threonyl- threonyl- lysyl- lysyl- arginine (PKCS)
7.	1,2- di- (4- sulfamidophenyl)- 4- butylpyrazolidine- 3,5- dione (DSB)