|1.||Greensmith, Linda: 4 articles (01/2014 - 04/2004)|
|2.||Kalmar, Bernadett: 3 articles (01/2014 - 04/2004)|
|3.||Greensmith, L: 2 articles (01/2014 - 12/2003)|
|4.||Kalmar, B: 2 articles (01/2014 - 12/2003)|
|5.||Wieland, Scott: 2 articles (12/2009 - 07/2008)|
|6.||Jednákovits, Andrea: 2 articles (06/2002 - 06/2002)|
|7.||Kürthy, Maria: 2 articles (06/2002 - 06/2002)|
|8.||Coffey, P J: 1 article (01/2014)|
|9.||Athanasiou, D: 1 article (01/2014)|
|10.||Aguila, M: 1 article (01/2014)|
10/01/2008 - "Late stage treatment with arimoclomol delays disease progression and prevents protein aggregation in the SOD1 mouse model of ALS."
10/01/2008 - "We have previously shown that treatment with a co-inducer of the heat shock response called arimoclomol is effective in the SOD(G93A) mouse model of ALS, delaying disease progression and extending the lifespan of SOD(G93A) mice (Kieran et al. 2004). "
04/01/2004 - "Treatment with arimoclomol, a coinducer of heat shock proteins, delays disease progression in ALS mice."
04/01/2004 - "Here we show that treatment with arimoclomol, a coinducer of heat shock proteins (HSPs), significantly delays disease progression in mice expressing a SOD1 mutant in which glycine is substituted with alanine at position 93 (SOD1(G93A)). "
03/01/2013 - "We have previously shown that treatment with arimoclomol, a co-inducer of the heat shock stress response, delays disease progression in the mutant superoxide dismutase 1 mouse model of amyotrophic lateral sclerosis, a fatal motor neuron disease. "
|2.||Neurodegenerative Diseases (Neurodegenerative Disease)
01/01/2014 - "Therefore, by targeting multiple pathological mechanisms, compounds such as Arimoclomol may be particularly effective in the development of a disease-modifying therapy for ALS and other neurodegenerative disorders."
03/01/2013 - "These results provide evidence that upregulation of the heat shock response by treatment with arimoclomol may have therapeutic potential in the treatment of spinal and bulbar muscular atrophy and may also be a possible approach for the treatment of other neurodegenerative diseases."
01/01/2014 - "Arimoclomol has been found to be neuroprotective in a number of neurodegenerative disease models, including Amyotrophic Lateral Sclerosis (ALS), and in mutant Superoxide Dismutase 1 (SOD1) mice that model ALS, Arimoclomol rescues motor neurons, improves neuromuscular function and extends lifespan. "
01/01/2011 - " data suggest that the arimoclomol treatment reduces the hypoxia-induced stress in brain tissue, and also improves the behavioral performance in rats during hypoxic adaptation."
01/01/2011 - "Results show that both cognitive and motor performances were improved in rats treated with arimoclomol during hypoxic exposure; the hypoxia-induced expression of HSP70 and ICAM-1, and TUNEL-positive cells were reduced in brain with the treatment.Our"
01/01/2011 - "We investigated the effect of a heat-shock protein co-inducer, arimoclomol (CytRx, LA, CA), on hypoxia-adaptive responses using a rat model of simulated altitude exposure (hypobaric hypoxia).Cognitive function was measured using a T-maze and an object recognition test.Motor"
|4.||Peripheral Nervous System Diseases (PNS Diseases)
06/01/2002 - "Effect of BRX-220 against peripheral neuropathy and insulin resistance in diabetic rat models."
06/01/2002 - "The effect of BRX-220 on peripheral neuropathy was examined in rats with diabetes (type 1) induced by administration of a beta-cell toxin, streptozotocin (STZ, 45 mg/kg iv). "
12/01/2003 - "In this study, we examined the effect BRX-220, a co-inducer of heat shock proteins, in injury-induced peripheral neuropathy. "
|5.||Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease)
07/01/2008 - "Arimoclomol at dosages up to 300 mg/day is well tolerated and safe in amyotrophic lateral sclerosis."
01/01/2014 - "The role of heat shock proteins in Amyotrophic Lateral Sclerosis: The therapeutic potential of Arimoclomol."
07/01/2010 - "Arimoclomol, a coinducer of heat shock proteins for the potential treatment of amyotrophic lateral sclerosis."
12/01/2009 - "Arimoclomol, an amplifier of heat shock protein expression involved in cellular stress response, has emerged as a potential therapeutic candidate in amyotrophic lateral sclerosis (ALS) in recent years. "
07/01/2008 - "Arimoclomol is an investigational drug for amyotrophic lateral sclerosis (ALS) that amplifies heat shock protein gene expression during cell stress. "
|2.||Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)
|3.||Heat-Shock Proteins (Heat-Shock Protein)
|4.||5,6- dihydro- 5- (1- piperidinyl)methyl- 3- (3- pyridil)- 4H- 1,2,4- oxa- diazine
|5.||superoxide dismutase 1
|8.||Rhodopsin (Visual Purple)
|10.||Glycine (Aminoacetic Acid)