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NCX 899

a nitric oxide donor and ACE inhibitor

Also Known As:

NCX-899; NCX899

Networked: 2 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - Dipeptides: 945
      - Enalapril: 3647
        NCX 899: 2

Experts

1.	Antunes, Edson: 1 article (04/2007)
2.	Astigarraga, Rafael E B: 1 article (04/2007)
3.	De Nucci, Gilberto: 1 article (04/2007)
4.	Faro, Renato: 1 article (04/2007)
5.	Lagos, Rodolfo Monaco: 1 article (04/2007)
6.	Mendes, Gustavo Duarte: 1 article (04/2007)
7.	Okuyama, Cristina E: 1 article (04/2007)
8.	Rezende, Vinicius M: 1 article (04/2007)
9.	Condorelli, Gianluigi: 1 article (03/2004)
10.	Del Soldato, Piero: 1 article (03/2004)

Related Diseases

1.	Heart Failure 03/01/2004 - "The superior effects of NO-releasing enalapril (NCX) vs. enalapril alone to enhance vascular effects, increase LV contractility and prevent unfavorable remodeling and are consistent with vascular delivery of exogenous NO. NCX 899 may hold promise for the future treatment of heart failure." 03/01/2004 - "A new compound (NCX 899), a NO-releasing derivative of enalapril was characterized, and its actions were evaluated in Bio 14.6 cardiomyopathic (CM) hamsters with heart failure. " 03/01/2004 - "A nitric oxide-releasing derivative of enalapril, NCX 899, prevents progressive cardiac dysfunction and remodeling in hamsters with heart failure."
2.	Hypertension (High Blood Pressure) 04/01/2007 - "The compound NCX899 significantly attenuated both arterial hypertension and bradycardia, whereas enalapril had no significant effect. " 04/01/2007 - "The effects of both enalapril and NCX899 in the arterial hypertension and bradycardia induced by acute NO inhibition in anaesthetized dogs were also investigated. "
3.	Bradycardia 04/01/2007 - "The compound NCX899 significantly attenuated both arterial hypertension and bradycardia, whereas enalapril had no significant effect. " 04/01/2007 - "The effects of both enalapril and NCX899 in the arterial hypertension and bradycardia induced by acute NO inhibition in anaesthetized dogs were also investigated. "

Related Drugs and Biologics

1.	Enalapril
2.	Nitric Oxide (Nitrogen Monoxide)