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elatol

RN given for (2R-(2alpha,3alpha,6alpha))-isomer; has antibacterial activity; structure in first source

Networked: 5 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Spiro Compounds: 2
      - elatol: 5
Polycyclic Compounds: 6
- Spiro Compounds: 2
  - elatol: 5

Experts

1.	Colepicolo, Pio: 1 article (01/2022)
2.	Dos Santos, Guilherme Senna: 1 article (01/2022)
3.	Falkenberg, Miriam: 1 article (01/2022)
4.	Miyasato, Patrícia Aoki: 1 article (01/2022)
5.	Nakano, Eliana: 1 article (01/2022)
6.	Pereira, Carlos Alberto de Bragança: 1 article (01/2022)
7.	Stein, Erika Mattos: 1 article (01/2022)
8.	Wright, Anthony D: 1 article (01/2022)
9.	Barcellos Marini, Maíra: 1 article (06/2018)
10.	Correa Ramos Leal, Ivana: 1 article (06/2018)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2018 - ": Elatol's identification as an eIF4A1 inhibitor with in vivo antitumor activities provides proof of principle for target-based screening against this highly promising target for cancer therapy. " 01/01/2018 - ": We found elatol is a specific inhibitor of ATP hydrolysis by eIF4A1 in vitro with broad activity against multiple tumor types. " 06/01/2018 - "In the present study, 6 sesquiterpenes (obtusol, (-)-elatol, dendoidiol, debrome-elatol, triquinane, and obtusane) isolated from Laurencia dendroidea were investigated for their cytotoxicity, using 4 cancer cell lines (U937, Jurkat, B16F10, and Colo-205). "
2.	Schistosomiasis (Bilharziasis) 01/29/2022 - "In the present study, three seaweed-derived halogenated sesquiterpenes, (-)-elatol, rogiolol, and obtusol are proposed as potential lead compounds for the development of anthelminthic drugs for the treatment of and pesticides for the environmental control of schistosomiasis. "
3.	Mitochondrial Diseases (Mitochondrial Disease) 08/01/2012 - "Trypanocidal action of (-)-elatol involves an oxidative stress triggered by mitochondria dysfunction."
4.	Pneumonia (Pneumonitis) 07/01/2003 - "Elatol (1) inhibited six species of bacteria, with significant antibacterial activities against Staphylococcus epidermis, Klebsiella pneumonia and Salmonella sp. while iso-obtusol (2) exhibited antibacterial activity against four bacterial species with significant activity against K. " 07/01/2003 - "pneumonia and Salmonella sp. Elatol (1) showed equal and better antibacterial activity compared with tested commercial antibiotics while iso-obtusol (2) only equaled the potency of commercial antibiotics against K. "
5.	Lymphoma (Lymphomas) 01/01/2018 - "Elatol is less potent in vitro than the well-studied eIF4A1 inhibitor silvestrol but is tolerated in vivo at approximately 100× relative dosing, leading to significant activity against lymphoma xenografts.Conclusions"

Related Drugs and Biologics

1.	Sesquiterpenes
2.	obtusol
3.	rogiolol
4.	Anti-Bacterial Agents (Antibiotics)
5.	Adenosine Triphosphate (ATP)
6.	silvestrol
7.	isoobtusol

Related Therapies and Procedures

1.	Therapeutics