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BB81384

a peptide deformylase inhibitor; structure in first source

Also Known As:

BB-81384

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Piperazines: 26
    - BB81384: 1

Experts

1.	Beckett, R P: 1 article (03/2004)
2.	Chen, H: 1 article (03/2004)
3.	Clements, J: 1 article (03/2004)
4.	Difuntorum, S: 1 article (03/2004)
5.	Garcia, M: 1 article (03/2004)
6.	Gross, M: 1 article (03/2004)
7.	Hoch, U: 1 article (03/2004)
8.	Johnson, K W: 1 article (03/2004)
9.	Lofland, D: 1 article (03/2004)
10.	Ramanathan-Girish, S: 1 article (03/2004)

Related Diseases

1.	Peritonitis 03/01/2004 - "Single-administration oral efficacy in a mouse peritonitis model was evident with an ED(50) of 30 mg/kg. BB-81384 reduced the bacterial load by approximately 5 and 3 log units in organ-burden models of lung and thigh infection, respectively. "
2.	Infections 03/01/2004 - "Single-administration oral efficacy in a mouse peritonitis model was evident with an ED(50) of 30 mg/kg. BB-81384 reduced the bacterial load by approximately 5 and 3 log units in organ-burden models of lung and thigh infection, respectively. " 03/01/2004 - "BB-81384, a novel peptide deformylase (PDF) inhibitor, was characterized in terms of enzyme inhibition profile, antibacterial activity, rodent pharmacokinetics and oral efficacy in murine infection models. "

Related Drugs and Biologics

1.	Enzymes
2.	peptide deformylase

Related Therapies and Procedures

1.	Oral Administration