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VX680

a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth; structure in first source
Also Known As:
MK-0457; VE 465; VE-465; VE465 cpd; VX-680; cyclopropane carboxylic acid(4-(4-(4-methylpiperazin-1-yl)-6-(5-methyl-2H-pyrazol-3-ylamino)pyrimidin-2-ylsulfanyl)phenyl)amide
Networked: 56 relevant articles (4 outcomes, 22 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Liu, Quentin: 6 articles (11/2013 - 03/2008)
2. Long, Zi-Jie: 4 articles (11/2013 - 01/2009)
3. Yan, Min: 4 articles (11/2013 - 03/2008)
4. Xu, Jie: 4 articles (08/2009 - 03/2008)
5. Cheng, Ann-Lii: 3 articles (07/2014 - 03/2009)
6. Lin, Zhong-Zhe: 3 articles (07/2014 - 03/2009)
7. Zheng, Fei-Meng: 3 articles (11/2013 - 03/2008)
8. Lin, Dong-Jun: 3 articles (11/2013 - 01/2009)
9. Ohyashiki, Kazuma: 3 articles (11/2010 - 06/2008)
10. Okabe, Seiichi: 3 articles (11/2010 - 06/2008)

Related Diseases

1. Leukemia
2. Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
3. Philadelphia Chromosome
4. Carcinoma (Carcinomatosis)
5. Glioblastoma (Glioblastoma Multiforme)

Related Drugs and Biologics

1. aurora kinase (aurora A kinase)
2. vorinostat (suberoylanilide hydroxamic acid)
3. Carboplatin (JM8)
4. VX680
5. Histones (Histone)
6. 4- (4- (N- benzoylamino)anilino)- 6- methoxy- 7- (3- (1- morpholino)propoxy)quinazoline
7. imatinib (Gleevec)
8. Histone Deacetylase Inhibitors
9. Protein Kinases (Protein Kinase)
10. Adenosine Triphosphate (ATP)

Related Therapies and Procedures

1. Heterologous Transplantation (Xenotransplantation)
2. Radiotherapy
3. Stem Cell Transplantation
4. Drug Therapy (Chemotherapy)