|1.||Dunford, Paul J: 4 articles (04/2010 - 04/2004)|
|2.||Thurmond, Robin L: 4 articles (04/2010 - 04/2004)|
|3.||Neumann, Detlef: 3 articles (11/2013 - 11/2009)|
|4.||Seifert, Roland: 3 articles (11/2013 - 11/2009)|
|5.||Beermann, Silke: 3 articles (11/2013 - 11/2009)|
|6.||Glage, Silke: 2 articles (11/2013 - 01/2012)|
|7.||Cowden, Jeffery M: 2 articles (04/2010 - 01/2010)|
|8.||Riley, Jason P: 2 articles (01/2010 - 04/2004)|
|9.||Hartwig, Christina: 1 article (11/2013)|
|10.||Burhenne, Heike: 1 article (11/2013)|
06/01/2010 - "Histamine H4 receptor antagonist, JNJ 7777120, could relieve symptoms and inflammatory conditions in allergic rhinitis, the effect was weak compared with Loratadine. "
06/01/2010 - "To clarify the effect of histamine H4 receptor antagonist, JNJ 7777120, and histamine H1 receptor antagonist, Loratadine, on allergic rhinitis (AR) in rats and to study the role of histamine H4 receptor antagonist and histamine H1 receptor antagonist in the pathogenesis of allergic rhinitis and therapeutic value of their antagonist. "
01/01/2010 - "After inflammation was established mice were dosed with the H4R antagonist, JNJ 7777120, or anti-IL-13 antibody for comparison. "
04/01/2004 - "Selective H4 receptor antagonists like JNJ 7777120 may have the potential to be useful in treating inflammation in humans."
09/01/2013 - "Here we report the effects of compound JNJ 7777120 (JNJ), a selective H4 receptor antagonist, on antigen-induced airway inflammation, paying special attention to its effects on lipocortin-1 (LC-1/annexin-A1), a 37 kDA anti-inflammatory protein that plays a key role in the production of inflammatory mediators. "
01/01/2007 - "We propose that the increase in mechanical hyperalgesia produced by thioperamide and JNJ 7777120 and the decrease in mechanical hyperalgesia produced by VUF 8430 may represent a direct effect of these agents on mechanospecific primary afferents, or an indirect effect of these agents via injury-induced inflammation."
|3.||Asthma (Bronchial Asthma)
11/01/2013 - "JNJ 7777120 provides beneficial effects in experimental murine asthma, which, however, could only partially be mimicked by thioperamide, despite more favorable pharmacokinetics. "
11/01/2013 - "In a murine model of allergic asthma, the histamine H4 receptor (H4R)-selective ligand JNJ 7777120 reduces asthma-like symptoms. "
01/01/2012 - "JNJ 7777120 and/or mepyramine were injected subcutaneously either during sensitization or during provocation, and typical asthma parameters were analyzed. "
11/01/2013 - "The dual H3/4R antagonist thioperamide does not fully mimic the effects of the 'standard' H4R antagonist JNJ 7777120 in experimental murine asthma."
01/01/2012 - "In a murine model of allergic asthma, JNJ 7777120, an antagonist at the histamine H(4) receptor, reduces asthmatic symptoms, while the histamine H(1) receptor-selective antagonist mepyramine is virtually without effect. "
04/01/2010 - "In addition to anti-inflammatory effects, JNJ 7777120 also significantly inhibited the pruritus shown in the model. "
09/08/2011 - "Pitolisant (50 nmol/injection)-induced pruritus could be completely blocked by a combined treatment with the H1R antagonist cetirizine (15 mg/kg) and the H4R antagonist JNJ 7777120 (15 mg/kg), whereas the H2R antagonist ranitidine (15 mg/kg) failed to inhibit the scratch response. "
11/01/2013 - "Nevertheless, JNJ 7777120 reduced serum titers of allergen-specific (anti-OVA) IgE, inflammatory infiltrations in lung tissue, and eosinophilia in bronchoalveolar lavage fluid. "
01/01/2012 - "JNJ 7777120, but not mepyramine, reduced serum concentrations of anti-OVA IgE, inflammatory infiltrations in lung tissue, and eosinophilia in bronchoalveolar-lavage (BAL)-fluids independently of the timing of application. "
|1.||Histamine (Histamine Dihydrochloride)
|3.||Histamine H1 Receptors (Histamine H1 Receptor)
|5.||Immunoglobulin E (IgE)