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sodium salt 1- ((5- (2- (5- chloro- o- anisamido)ethyl)- beta- methoxyethoxyphenyl)sulfonyl)- 3- methylthiourea

structure in first source

Also Known As:

1-((5-(2-(5-chloro-o-anisamido)ethyl)-beta-methoxyethoxyphenyl)sulfonyl)-3-methylthiourea, sodium salt; HMR 1402

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amides: 2428
  - Urea: 15015
    - Thiourea: 362
      - sodium salt 1-((5-(2-(5-chloro-o-anisamido)ethyl)-beta-methoxyethoxyphenyl)sulfonyl)-3-methylthiourea: 1
- Sulfur Compounds: 278
  - Thiourea: 362
    - sodium salt 1-((5-(2-(5-chloro-o-anisamido)ethyl)-beta-methoxyethoxyphenyl)sulfonyl)-3-methylthiourea: 1

Experts

1.	Billman, George E: 1 article (04/2004)
2.	Englert, Heinrich C: 1 article (04/2004)
3.	Gögelein, Heinz: 1 article (04/2004)
4.	Houle, Melanie S: 1 article (04/2004)

Related Diseases

1.	Myocardial Ischemia (Ischemic Heart Diseases) 04/01/2004 - "Effects of a novel cardioselective ATP-sensitive potassium channel antagonist, 1-[[5-[2-(5-chloro-o-anisamido)ethyl]-beta-methoxyethoxyphenyl]sulfonyl]-3-methylthiourea, sodium salt (HMR 1402), on susceptibility to ventricular fibrillation induced by myocardial ischemia: in vitro and in vivo studies."
2.	Ventricular Fibrillation 04/01/2004 - "These data strongly suggest that HMR 1402 has pharmacological selectivity for cardiac myocytes and, therefore, may protect against ischemically induced ventricular fibrillation (VF) without the untoward effects of nonselective compounds. " 04/01/2004 - "Effects of a novel cardioselective ATP-sensitive potassium channel antagonist, 1-[[5-[2-(5-chloro-o-anisamido)ethyl]-beta-methoxyethoxyphenyl]sulfonyl]-3-methylthiourea, sodium salt (HMR 1402), on susceptibility to ventricular fibrillation induced by myocardial ischemia: in vitro and in vivo studies."
3.	Ischemia 04/01/2004 - "On a subsequent day, the exercise plus ischemia test was repeated after HMR 1402 (3.0 mg/kg i.v., n = 4, infusion 4 microg/kg/min for 1 h before exercise, n = 4). "
4.	Insulinoma 04/01/2004 - "In contrast, HMR 1402 had a smaller effect on pancreatic beta-cells (rat insuloma cells, RINm5F) hyperpolarized with 100 microM diazoxide (IC(50) = 3.9 microM, compared with glibenclamide IC(50) = 9 nM). "
5.	Hypoxia (Hypoxemia) 04/01/2004 - "In a similar manner, hypoxia induced increases in coronary flow in isolated guinea pig hearts were only slightly reduced by HMR 1402. " 04/01/2004 - "Hypoxia-induced shortening of action potential duration at 90% repolarization was also significantly attenuated by HMR 1402 (68.1 +/- 3.9% of control at 0.3 microM). "

Related Drugs and Biologics

1.	KATP Channels
2.	Sodium
3.	Salts
4.	Glyburide (Glibenclamide)
5.	Diazoxide (Hyperstat)