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3- ((4- hydroxy- 3- methoxyphenyl)- 2- propenoic acid 4-nitrooxy)butyl ester

Also Known As:

NCX 2057

Networked: 2 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Acyclic Hydrocarbons
    - Alkanes: 241
      - Butanes: 12
        3-((4-hydroxy-3-methoxyphenyl)-2-propenoic acid 4-nitrooxy)butyl ester: 2
- Nitro Compounds: 66
  - 3-((4-hydroxy-3-methoxyphenyl)-2-propenoic acid 4-nitrooxy)butyl ester: 2

Experts

1.	Impagnatiello, Francesco: 2 articles (09/2009 - 02/2006)
2.	Ronchetti, Daniela: 2 articles (09/2009 - 02/2006)
3.	Borghi, Valentina: 1 article (09/2009)
4.	Gaitan, Gema: 1 article (09/2009)
5.	Herrero, Juan F: 1 article (09/2009)
6.	Borgatti, Monica: 1 article (02/2006)
7.	Gambari, Roberto: 1 article (02/2006)
8.	Gasparini, Laura: 1 article (02/2006)
9.	Guzzetta, Massimiliano: 1 article (02/2006)
10.	Ongini, Ennio: 1 article (02/2006)

Related Diseases

1.	Neuralgia (Stump Neuralgia) 09/01/2009 - "These studies indicate that NCX 2057 is effective in chronic inflammatory and neuropathic pain models, probably because of its particular combination of anti-COX, antioxidant and NO-releasing properties." 09/01/2009 - "Here, we have assessed the activities of NCX 2057 in models of inflammatory and neuropathic pain, and characterized its effects on cyclooxygenase (COX)-1 and COX-2. "
2.	Inflammation (Inflammations) 02/17/2006 - "Thus, NCX 2057 represents a new prototype drug for the treatment of disorders associated with chronic inflammation and oxidative stress." 09/01/2009 - "NCX 2057 dose-dependently inhibited single motor unit responses to noxious mechanical stimulation (ID(50)= 100 micromol kg(-1)) and wind-up responses in rats with paw inflammation induced by carrageenan. "
3.	Pain (Aches) 09/01/2009 - "Anti-nociceptive and anti-inflammatory activities of NCX 2057 were measured in vitro and in vivo in models of inflammatory (carrageenan) and neuropathic (chronic constriction injury; CCI) pain. "
4.	Encephalitis (Encephalitis, Rasmussen) 02/17/2006 - "We have previously reported that NCX 2057, a new chemical entity bearing a nitric oxide (NO)-releasing moiety linked to the natural antioxidant ferulic acid, shows marked anti-inflammatory properties in a model of chronic brain inflammation. "

Related Drugs and Biologics

1.	Antioxidants
2.	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)
3.	Nitric Oxide (Nitrogen Monoxide)
4.	Carrageenan
5.	ferulic acid (sodium ferulate)