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3- (3- hydroxy- 4- methoxyphenyl)- 8H- thieno(2,3- b)pyrrolizin- 8- one

an antitubulin and antineoplastic agent; structure in first source

Also Known As:

3-HMeOPh-TPO; MR22388

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Alkaloids: 5398
  - Pyrrolizidine Alkaloids: 290
    - 3-(3-hydroxy-4-methoxyphenyl)-8H-thieno(2,3-b)pyrrolizin-8-one: 2
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Pyrrolizidine Alkaloids: 290
      - 3-(3-hydroxy-4-methoxyphenyl)-8H-thieno(2,3-b)pyrrolizin-8-one: 2

Experts

1.	Rault, Sylvain: 2 articles (06/2013 - 04/2013)
2.	Abeilard, Edwige: 1 article (06/2013)
3.	Brotin, Emilie: 1 article (06/2013)
4.	Gauduchon, Pascal: 1 article (06/2013)
5.	Giffard, Florence: 1 article (06/2013)
6.	Louis, Marie-Hélène: 1 article (06/2013)
7.	Malzert-Freon, Aurélie: 1 article (06/2013)
8.	Poulain, Laurent: 1 article (06/2013)
9.	Tomasina, Julie: 1 article (06/2013)
10.	Cresteil, Thierry: 1 article (04/2013)

Related Diseases

1.	Neoplasms (Cancer) 04/30/2013 - "This work describes the study of the mechanism of action and spectrum of activity of MR22388, a novel anti-cancer agent belonging to the tripentone series. " 04/30/2013 - "MR22388, a novel anti-cancer agent with a strong FLT-3 ITD kinase affinity." 04/30/2013 - "MR22388 is highly cytotoxic (within the nanomolar range) against numerous cancer cell lines and studies of its cytotoxicity mechanisms show that it is a weak inhibitor of the polymerization of tubulin and that it induces apoptosis via the MAP kinase pathways. "
2.	Ovarian Neoplasms (Ovarian Cancer) 06/05/2013 - "Here we studied the interest of a member of the tripentone chemical family, MR22388, for the treatment of chemoresistant ovarian cancer cells. " 06/05/2013 - "MR22388 activity has been assessed in vitro on cisplatin-resistant (SKOV3 and IGROV1-R10) ovarian cancer cell lines by conventional analysis, alone or combined to a BH3-mimetic molecule, ABT-737. "
3.	Carcinoma (Carcinomatosis) 06/05/2013 - "Sensitization of ovarian carcinoma cells to Bcl-xL-targeting strategies through indirect modulation of Mcl-1 activity by MR22388, a molecule of the tripentone family."

Related Drugs and Biologics

1.	Tubulin
2.	Phosphotransferases (Kinase)
3.	Cisplatin (Platino)
4.	ABT-737