|1.||Yao, Zhu-Jun: 8 articles (01/2015 - 11/2003)|
|2.||Jiang, Sheng: 4 articles (04/2014 - 11/2003)|
|3.||Mao, Chan: 3 articles (01/2015 - 01/2011)|
|4.||Liu, Hai-Xia: 3 articles (01/2012 - 06/2007)|
|5.||Han, Bing: 2 articles (01/2015 - 06/2012)|
|6.||Wang, Li-Shun: 2 articles (01/2015 - 06/2012)|
|7.||Zhou, Guang-Biao: 2 articles (04/2014 - 01/2012)|
|8.||Liu, Yongqiang: 2 articles (04/2014 - 01/2011)|
|9.||Wu, Jia-Rui: 2 articles (06/2007 - 11/2003)|
|10.||Huang, Guo-Rui: 2 articles (06/2007 - 11/2003)|
01/01/2012 - "In this study we tested the effects of a set of mimetics of annonaceous acetogenin on some cancer cell lines, and report that among them AA005 exhibits the most potent antitumor activity. "
06/15/2007 - "Bioactivity study against cancer cells shows that the N-methylated lactam-containing compounds 3, 4, and 5 exhibit comparable potencies to that of AA005, as well as the similar selectivity to cancer cells. "
04/01/2014 - "Among these, compound 7 bearing a homopiperazine ring in the middle region exhibited more potent growth inhibitory activity and higher selectivity against cancer cells over normal cells by comparison with AA005. "
01/27/2011 - "The first generation of annonaceous acetogenin mimetic (1, AA005) exhibits comparable activity as that of natural products and presents much higher selectivity between cancer and normal cells. "
11/07/2003 - "It was found that AA005 can induce the cell death of gastric tumor cells. "
|2.||Acute Promyelocytic Leukemia
06/01/2012 - "The vast majority of cells went to die after leukemia cell lines of NB4, U937 and K562 were treated with different concentration of AA005 for 48 h. "
06/01/2012 - "The results showed that AA005 (> 200 nmol/L) significantly inhibited proliferation of all tested leukemia cell lines in a concentration-dependent manner. "
06/01/2012 - "It is concluded that annonaceous acetogenin mimic AA005 induces significant proliferative inhibition of various leukemia cell lines in a concentration-dependent manner, which may be associated with cell death and G(2)/M-phase arrest induced by AA005."
06/01/2012 - "[Effect of annonaceous acetogenin mimic AA005 on proliferative inhibition of leukemia cells in vitro and its possible mechanisms]."
06/01/2012 - "This study was aimed to investigate the biological behavior of annonaceous acetogenin mimic AA005 in various kinds of leukemia cells and further elaborated its possible mechanisms in acute promyelocytic leukemia (APL) cell line NB4. "
01/01/2015 - "We used SW620 colorectal adenocarcinoma cells to study AA005 cytotoxic activity. "
01/01/2015 - "AA005 induces a unique type of cell death in colorectal adenocarcinoma cells, characterized by lack of caspase-3 activation or apoptotic body formation, sensitivity to poly (ADP-ribose) polymerase inhibitor Olaparib (AZD2281) but not pan-caspase inhibitor Z-VAD.fmk, and dependence on apoptosis-inducing factor (AIF). "
|5.||Stomach Neoplasms (Stomach Cancer)
|2.||Electron Transport Complex I (NADH-CoQ Reductase)
|4.||AMP-Activated Protein Kinases
|6.||Caspase 3 (Caspase-3)
|7.||Apoptosis Inducing Factor
|8.||Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)
|9.||Ethyl Ether (Ether)