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hydroxymethylnitrofurazone

structure in first source

Also Known As:

NFOH-121

Networked: 5 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Nitro Compounds: 66
  - Nitrofurans: 69
    - Nitrofurazone: 253
      - hydroxymethylnitrofurazone: 5
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Furans: 85
    - Nitrofurans: 69
      - Nitrofurazone: 253
        hydroxymethylnitrofurazone: 5

Experts

1.	Ferreira, Elizabeth Igne: 2 articles (06/2021 - 12/2013)
2.	Chung, Man Chin: 2 articles (12/2013 - 09/2010)
3.	Chin, Chung Man: 1 article (06/2021)
4.	Fortes Francisco, Amanda: 1 article (06/2021)
5.	Kelly, John M: 1 article (06/2021)
6.	Olmo, Francisco: 1 article (06/2021)
7.	Scarim, Cauê Benito: 1 article (06/2021)
8.	Barbosa, Eduardo José: 1 article (09/2020)
9.	Bou-Chacra, Nádia Araci: 1 article (09/2020)
10.	Calixto, Leandro Augusto: 1 article (09/2020)

Related Diseases

1.	Chagas Disease (American Trypanosomiasis) 06/28/2021 - "Hydroxymethylnitrofurazone (NFOH) is a therapeutic candidate for Chagas disease (CD). " 09/01/2010 - "Hydroxymethylnitrofurazone is active in a murine model of Chagas' disease." 10/01/2018 - "Hydroxymethylnitrofurazone treatment in indeterminate form of chronic Chagas disease: Reduced intensity of tissue parasitism and inflammation-A histopathological study." 12/01/2013 - "Pharmacokinetics of hydroxymethylnitrofurazone, a promising new prodrug for Chagas' disease treatment." 09/01/2010 - "The addition of a hydroxymethyl group to the antimicrobial drug nitrofurazone generated hydroxymethylnitrofurazone (NFOH), which had reduced toxicity when its activity against Trypanosoma cruzi was tested in a murine model of Chagas' disease. "
2.	Inflammation (Inflammations) 10/01/2018 - "Hydroxymethylnitrofurazone treatment in indeterminate form of chronic Chagas disease: Reduced intensity of tissue parasitism and inflammation-A histopathological study."
3.	Leishmaniasis 09/01/2020 - "A new medium-throughput screening design approach for the development of hydroxymethylnitrofurazone (NFOH) nanostructured lipid carrier for treating leishmaniasis."
4.	Infections 10/01/2018 - "Hydroxymethylnitrofurazone (NFOH) is a nitrofurazone prodrug effective in vivo during acute infections, and it has less hepatotoxicity effect than the standard drug benznidazole (BZN) which has been used during short- and long-term treatment. "

Related Drugs and Biologics

1.	Prodrugs
2.	Nitrofurazone (Nitrofural)
3.	Lipids
4.	benzonidazole (benznidazole)