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5- (3- (3- (4- phenoxy- 2- propylphenoxy)propoxy)phenyl)- 2,4- thiazolidinedione

a peroxisome proliferator-activated receptor (PPAR)-alpha and gamma dual agonist with antilipemic activity; structure in first source

Also Known As:

TZD 18; TZD-18; TZD18

Networked: 6 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Elstner, Elena: 4 articles (08/2009 - 10/2004)
2.	Possinger, Kurt: 4 articles (08/2009 - 10/2004)
3.	Koeffler, H Phillip: 3 articles (08/2009 - 05/2006)
4.	Liu, Hongyu: 3 articles (08/2009 - 05/2006)
5.	Zang, Chuanbing: 3 articles (08/2009 - 05/2006)
6.	Bertz, Janina: 2 articles (08/2009 - 10/2006)
7.	Eucker, Jan: 2 articles (08/2009 - 10/2006)
8.	Li, Ling: 1 article (01/2019)
9.	Ma, Yuhong: 1 article (01/2019)
10.	Wang, Bin: 1 article (01/2019)

Related Diseases

1.	Blast Crisis (Blast Phase) 10/01/2006 - "Overall, our findings strongly suggest that either TZD18, either alone or in combination with imatinib may be beneficial for the treatment of CML in myeloid blast crisis."
2.	Leukemia 05/01/2006 - "In addition, TZD18 enhanced the growth inhibitory effect of imatinib, a specific tyrosine kinase inhibitor therapeutically used in the treatment of Ph(+) leukemia. " 08/01/2009 - "Previously we reported that the peroxisome proliferator-activated receptor alpha/gamma dual ligand TZD18 inhibited growth and induced apoptosis of leukemia and glioblastoma cells. "
3.	Glioblastoma (Glioblastoma Multiforme) 10/01/2004 - "TZD18, a novel PPARalpha/gamma dual agonist, inhibited cell growth and induce apoptosis in human glioblastoma T98G cells in vitro, indicating a therapeutic potential for TZD18 in the treatment of glioblastoma." 10/01/2004 - "To examine the effect of a novel peroxisome proliferator-activated receptor (PPAR) alpha/gamma dual agonist TZD18 on cell proliferation and apoptosis in human glioblastoma T98G cells and its possible mechanism. " 08/01/2009 - "Previously we reported that the peroxisome proliferator-activated receptor alpha/gamma dual ligand TZD18 inhibited growth and induced apoptosis of leukemia and glioblastoma cells. "
4.	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 05/01/2006 - "Growth inhibition and apoptosis in human Philadelphia chromosome-positive lymphoblastic leukemia cell lines by treatment with the dual PPARalpha/gamma ligand TZD18."
5.	Stomach Neoplasms (Stomach Cancer) 01/01/2019 - "The administration of peroxisome proliferator-activated receptors α/γ agonist TZD18 inhibits cell growth and induces apoptosis in human gastric cancer cell lines."

Related Drugs and Biologics

1.	Imatinib Mesylate (Gleevec)
2.	PPAR alpha
3.	Ligands
4.	Peroxisome Proliferator-Activated Receptors (PPAR)
5.	Messenger RNA (mRNA)
6.	Phosphates (Orthophosphate)
7.	Bromides
8.	Tyrosine Kinase Inhibitors
9.	salicylhydroxamic acid (SHAM)