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2- ((3- (2,3- dichlorophenoxy)propyl)amino)ethanol

apoptosis-inducing agent that down-regulates Bcl-XL in cancer cells; structure in first source

Also Known As:

2,3-DCPE

Networked: 5 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Zhu, Hongbo: 3 articles (12/2020 - 02/2004)
2.	Davis, John J: 2 articles (06/2004 - 02/2004)
3.	Fang, Bingliang: 2 articles (06/2004 - 02/2004)
4.	Teraishi, Fuminori: 2 articles (06/2004 - 02/2004)
5.	Wu, Shuhong: 2 articles (06/2004 - 02/2004)
6.	Zhang, Lidong: 2 articles (06/2004 - 02/2004)
7.	Bai, Bingjun: 1 article (12/2020)
8.	Chen, Kangke: 1 article (12/2020)
9.	Hu, Jinhui: 1 article (12/2020)
10.	Lv, Yiming: 1 article (12/2020)

Related Diseases

1.	Neoplasms (Cancer) 06/24/2004 - "Here, we found that 2,3-DCPE suppressed the proliferation of Bcl-XL-overexpressing cancer cells without inducing apoptosis. " 02/01/2004 - "Subsequent studies revealed that 2,3-DCPE could cause cleavage of caspase-8, caspase-3, caspase-9, and poly(ADP-ribose) polymerase and release of cytochrome c in cancer cells but not in normal human fibroblasts. "
2.	Colonic Neoplasms (Colon Cancer) 12/01/2020 - "Taken together, the data of the current study indicated that 2,3-DCPE caused DNA damage in colon cancer cells and that 2,3-DCPE-induced S phase arrest was associated with the activation of the ATM/ATR-Chk1-Cdc25A pathway." 12/01/2020 - "Small molecule 2,3-DCPE induces S phase arrest by activating the ATM/ATR-Chk1-Cdc25A signaling pathway in DLD-1 colon cancer cells." 06/24/2004 - "Subsequently, we found that 2,3-DCPE could induce S-phase arrest and upregulate p21 but not p27 at a time- and dose-dependent but p53-dispensable manner in DLD-1 human colon cancer cells. " 12/01/2020 - "The results demonstrated that 2,3-DCPE upregulated phosphorylated (p-)H2A histone family member X, a biomarker of DNA damage, in the DLD-1 colon cancer cell line. "
3.	Neuroblastoma 11/01/2011 - "In conclusion, our results appeared highly encouraging in advocating the use of 2,3-DCPE and 4-HPR as a novel combination therapy for increasing both differentiation and apoptosis in human malignant neuroblastoma cells having Bcl-x(L) overexpression."
4.	Carcinoma (Carcinomatosis) 05/01/2007 - "Anticancer and chemosensitizing effects of 2,3-DCPE in ovarian carcinoma cell lines: link with ERK activation and modulation of p21WAF1/CIP1, Bcl-2 and Bcl-xL expression." 05/01/2007 - "Our results emphasized the potential interest of 2,3-DCPE, used alone or combined with cisplatin, for ovarian carcinoma treatment. " 05/01/2007 - "Moreover, 2,3-DCPE exerted a cytostatic effect on OAW42, IGROV1-R10 and SKOV3 ovarian carcinoma cells, the sensitivity to 2,3-DCPE appearing in particular linked with a low basal level of P-ERK. " 05/01/2007 - "We treated four ovarian carcinoma cell lines with 2,3-DCPE, alone or combined with cisplatin. "

Related Drugs and Biologics

1.	Caspase 9
2.	Caspase 8 (Caspase-8)
3.	Caspase 3 (Caspase-3)
4.	Cytochromes c (Cytochrome c)
5.	Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)
6.	Cytostatic Agents
7.	Fenretinide
8.	Biomarkers (Surrogate Marker)
9.	Histones (Histone)
10.	Cisplatin (Platino)

Related Therapies and Procedures

1.	Therapeutics