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2-hydroxyoleic acid

antihypertensive agent; a synthetic derivative of oleic acid

Also Known As:

2-OHOA compound

Networked: 16 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Lipids: 114793
- Fatty Acids: 27405
  - Unsaturated Fatty Acids: 8236
    - Monounsaturated Fatty Acids: 676
      - Oleic Acids: 67
        2-hydroxyoleic acid: 16

Experts

1.	Escribá, Pablo V: 8 articles (01/2019 - 12/2011)
2.	Busquets, Xavier: 7 articles (01/2019 - 01/2012)
3.	Barceló-Coblijn, Gwendolyn: 5 articles (06/2014 - 12/2011)
4.	Martin, Maria Laura: 4 articles (06/2014 - 12/2011)
5.	García-Verdugo, José Manuel: 4 articles (05/2013 - 01/2012)
6.	Soriano-Navarro, Mario: 4 articles (05/2013 - 01/2012)
7.	Marcilla-Etxenike, Amaia: 4 articles (10/2012 - 12/2011)
8.	Noguera-Salvà, Maria Antònia: 4 articles (10/2012 - 12/2011)
9.	Lladó, Victoria: 3 articles (01/2019 - 05/2012)
10.	Terés, Silvia: 3 articles (06/2014 - 05/2012)

Related Diseases

1.	Neoplasms (Cancer) 05/09/2023 - "2-Hydroxyoleic Acid as a Self-Assembly Inducer for Anti-Cancer Drug-Centered Nanoparticles." 01/01/2019 - "Studies on the Interactions of 2-Hydroxyoleic Acid with Monolayers and Bilayers Containing Cationic Lipid: Searching for the Formulations for More Efficient Drug Delivery to Cancer Cells." 12/27/2016 - "The anti-tumor drug 2-hydroxyoleic acid (Minerval) stimulates signaling and retrograde transport." 10/01/2012 - "Normalization of sphingomyelin levels by 2-hydroxyoleic acid induces autophagic cell death of SF767 cancer cells." 01/01/2012 - "2-Hydroxyoleic acid is a synthetic fatty acid with potent anti-cancer activity which does not induce undesired side effects. "
2.	Glioma (Gliomas) 05/29/2012 - "Here, we show that 2-hydroxyoleic acid (2OHOA) induces differentiation and autophagy of human glioma cells. " 01/01/2012 - "2-Hydroxyoleic acid induces ER stress and autophagy in various human glioma cell lines." 01/14/2019 - "Background: 2-Hydroxyoleic acid (2OHOA) is particularly active against glioblastoma multiforme (GBM) and successfully finished a phase I/IIA trial in patients with glioma and other advanced solid tumors. " 12/06/2011 - "Sphingomyelin and sphingomyelin synthase (SMS) in the malignant transformation of glioma cells and in 2-hydroxyoleic acid therapy."
3.	Glioblastoma (Glioblastoma Multiforme) 01/14/2019 - "Background: 2-Hydroxyoleic acid (2OHOA) is particularly active against glioblastoma multiforme (GBM) and successfully finished a phase I/IIA trial in patients with glioma and other advanced solid tumors. "
4.	Obesity 01/01/2017 - "We aimed to investigate the effects of obesity on oxidative stress and leucocyte function in the mouse spleen and to assess whether supplementation with 2-hydroxyoleic acid (2-OHOA) or n-3 polyunsaturated fatty acids (PUFAs) could reverse those effects. " 11/01/2019 - "We aimed to assess whether 2-hydroxyoleic acid (2-OHOA) and n-3 polyunsaturated fatty acids (PUFA) could counteract changes on adipokine secretion and cardiometabolic risk biomarkers associated with high-fat diet-induced obesity in mice. "
5.	Sphingolipidoses (Sphingolipidosis) 05/01/2013 - "Sustained activation of sphingomyelin synthase by 2-hydroxyoleic acid induces sphingolipidosis in tumor cells."

Related Drugs and Biologics

1.	Lipids
2.	Fatty Acids (Saturated Fatty Acids)
3.	phosphatidylcholine-ceramide phosphocholine transferase
4.	Sphingomyelins
5.	Membrane Lipids
6.	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)
7.	Endocannabinoids
8.	Adipokines
9.	Glutathione Disulfide (GSSG)
10.	Oleic Acid (Oleate)

Related Therapies and Procedures

1.	Therapeutics