|1.||Kaunitz, Jonathan D: 2 articles (12/2007 - 10/2005)|
|2.||Akiba, Yasutada: 2 articles (12/2007 - 10/2005)|
|3.||Quach, Kevin: 1 article (01/2015)|
|4.||Oke, Olufolarin O: 1 article (01/2015)|
|5.||Fleiszig, Suzanne M J: 1 article (01/2015)|
|6.||Evans, David J: 1 article (01/2015)|
|7.||Wen, Emily R: 1 article (01/2015)|
|8.||Chang, Stephanie W: 1 article (01/2015)|
|9.||Jolly, Amber L: 1 article (01/2015)|
|10.||Takawira, Desire: 1 article (01/2015)|
|1.||Cystic Fibrosis (Mucoviscidosis)
12/01/2007 - "Furthermore, incubation with a pH 2.2 solution reduced AP activity in vivo, whereas pretreatment with the cystic fibrosis transmembrane regulator (CFTR) inhibitor CFTR(inh)-172 abolished AP activity at pH 2.2. "
01/01/2015 - "Cells with defective CFTR displayed enhanced bleb formation upon infection, as demonstrated using bronchial epithelial cells from a patient with cystic fibrosis and a CFTR inhibitor, CFTR(Inh)-172. "
04/01/2010 - "Two highly potent and selective cystic fibrosis (CF) transmembrane regulator (CFTR) inhibitors have been identified by high-throughput screening: the thiazolidinone CFTR(inh)-172 [3-[(3-trifluoromethyl)phenyl]-5-[(4-carboxyphenyl)methylene]- 2-thioxo-4-thiazolidinone] and the glycine hydrazide GlyH-101 [N-(2-naphthalenyl)-((3,5-dibromo-2,4-dihydroxyphenyl)methylene)glycine hydrazide]. "
04/01/2010 - "Cystic fibrosis transmembrane regulator inhibitors CFTR(inh)-172 and GlyH-101 target mitochondrial functions, independently of chloride channel inhibition."
09/01/2008 - "THF increased I(sc) in Fischer rat thyroid (FRT) epithelia expressing wild-type CFTR with half-maximal effective concentration (K(D)) of 134 mM. This THF-induced increase in I(sc) was enhanced by forskolin (10 microM), inhibited by the PKA inhibitor H-89 (10 microM) and the thiazolidinone CFTR(inh)-172 (10 microM) and attenuated greatly in FRT epithelia expressing the cystic fibrosis mutants F508del- and G551D-CFTR. "
|2.||Wounds and Injuries (Trauma)
02/01/2014 - "Cell migration was measured and covered 11.2 ± 0.4, 24.0 ± 1.7 and 13.9 ± 1.0% of the wound when cells were cultivated under control, forskolin, and forskolin plus CFTR(inh)-172, respectively. "
10/01/2011 - "In addition, inhibiting cystic fibrosis transmembrane conductance regulator (CFTR) with CFTR(Inh)-172 significantly reduced wound currents (0.17 μA/cm(2)), implicating an important role of ion transporters in wound induced electric potentials. "
11/01/2010 - "Inhibition of CFTR-dependent anion transport by treatment with CFTR(inh)-172 slowed wound closure to the same extent as silencing CFTR protein expression, indicating that ion transport by CFTR plays a critical role in migration. "
11/01/2010 - "Selective inhibition of CFTR activity with CFTR(inh)-172 or short hairpin RNA silencing of CFTR expression produced a significant delay in wound repair. "
|1.||Cystic Fibrosis Transmembrane Conductance Regulator (Protein, CFTR)
|3.||Small Interfering RNA (siRNA)
|4.||Chloride Channels (Chloride Channel)
|10.||Adenosine Triphosphate (ATP)