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4-hydroxy-1-(3-pyridyl)-1-butanone

structure in first source

Also Known As:

HPB cpd

Networked: 3 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Ketones: 2618
  - Butanones
    - 4-hydroxy-1-(3-pyridyl)-1-butanone: 3
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - 4-hydroxy-1-(3-pyridyl)-1-butanone: 3

Experts

1.	Hölzle, Daniel: 1 article (04/2007)
2.	Richter, Elmar: 1 article (04/2007)
3.	Schlöbe, Daniela: 1 article (04/2007)
4.	Tricker, Anthony R: 1 article (04/2007)

Related Diseases

1.	Lung Neoplasms (Lung Cancer) 04/11/2007 - "An improved analytical method was developed for the analysis of 4-hydroxy-1-(3-pyridyl)-1-butanone (HPB)-releasing DNA adducts in lung samples of patients undergoing surgery for lung cancer. " 09/01/1998 - "Hemoglobin (Hb) adducts of 4-hydroxy-1-(3-pyridyl)-1-butanone (HPB), a metabolite of two tobacco-specific nitrosamines [4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and N'-nitrosonornicotine], were measured as biomarkers of exposure to tobacco smoke as part of a study on genetic alterations and susceptibility to lung cancer among nonsmokers. "
2.	Neoplasms (Cancer) 09/01/1996 - "Two biomarkers of NNK metabolism, 4-hydroxy-1-(3-pyridyl)-1-butanone (HPB)-releasing hemoglobin adducts and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) and its glucuronide (NNAL-Gluc) in urine, were also quantified during the course of the tumor induction experiment. "

Related Drugs and Biologics

1.	DNA Adducts
2.	Biomarkers (Surrogate Marker)
3.	Hemoglobins (Hemoglobin)
4.	Smoke
5.	Nitrosamines
6.	N'-nitrosonornicotine (nitrosonornicotine)
7.	Glucuronides
8.	4- (methylnitrosamino)- 1- (3- pyridyl)- 1- butan- 1- ol
9.	4- ((methylnitrosoamino)- 1- (3- pyridyl)but- 1- yl)beta- omega- glucosiduronic acid