topovale

topoisomerase I-targeting anticancer drug; structure in first source

Also Known As:

8,9-dimethoxy-5-(2-N,N-dimethylaminoethyl)-2,3-methylenedioxy-5H-dibenzo(c,h)(1,6)naphthyridin-6-one; ARC-111; ARC111

Networked: 6 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Naphthyridines: 2
      - topovale: 6

Experts

1.	Bagley, Rebecca G: 2 articles (05/2011 - 10/2008)
2.	Crawford, Jennifer: 2 articles (05/2011 - 10/2008)
3.	Krumbholz, Roy: 2 articles (05/2011 - 10/2008)
4.	Kurtzberg, Leslie S: 2 articles (05/2011 - 10/2008)
5.	Lavoie, Edmond J: 2 articles (05/2011 - 10/2008)
6.	Roth, Stephanie: 2 articles (05/2011 - 10/2008)
7.	Rouleau, Cecile: 2 articles (05/2011 - 10/2008)
8.	Teicher, Beverly A: 2 articles (05/2011 - 10/2008)
9.	Wang, Fei: 2 articles (05/2011 - 10/2008)
10.	Yao, Min: 2 articles (05/2011 - 10/2008)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2012 - "To design ARC-111 analogues with improved efficiency, we constructed the QSAR of 22 ARC-111 analogues with RPMI8402 tumor cells. " 12/01/2003 - "In the current study, we show that ARC-111 is highly potent in scid mice carrying human tumor xenografts. " 12/01/2003 - "In tissue culture models, ARC-111 exhibited low nM cytotoxicity against a panel of cancer cells. " 04/01/2007 - "The results indicate that inhibiting hypoxia-inducible factor-1alpha accumulation and exhibiting antiproliferation of ARC-111 are through distinct mechanisms of action, which reinforce the potential anticancer effect of ARC-111 on hypoxic tumors." 04/01/2007 - "In addition to inhibiting hypoxia-induced accumulation of hypoxia-inducible factor-1alpha, ARC-111 exhibits antiproliferative effects against multiple human cancer cell lines. "
2.	Hypoxia (Hypoxemia) 04/01/2007 - "In this study, we explore the potential of ARC-111 as a hypoxia-inducible factor-1alpha inhibitor under hypoxic conditions. " 04/01/2007 - "We demonstrate that inhibition of hypoxia-inducible factor-1alpha accumulation by ARC-111 is independent of proteasomal degradation. " 04/01/2007 - "ARC-111 inhibits hypoxia-mediated hypoxia-inducible factor-1alpha accumulation." 04/01/2007 - "The results indicate that inhibiting hypoxia-inducible factor-1alpha accumulation and exhibiting antiproliferation of ARC-111 are through distinct mechanisms of action, which reinforce the potential anticancer effect of ARC-111 on hypoxic tumors." 04/01/2007 - "In addition to inhibiting hypoxia-induced accumulation of hypoxia-inducible factor-1alpha, ARC-111 exhibits antiproliferative effects against multiple human cancer cell lines. "
3.	Wilms Tumor (Wilm's Tumor) 12/01/2003 - "ARC-111 was shown to be as active as camptothecin (CPT)-11 in the HCT-8 colon tumor model, and compared favorably with CPT-11 and topotecan in the SKNEP anaplastic Wilms' tumor model. "
4.	Medulloblastoma 02/10/2005 - "Comparative studies on the antitumor activity of ARC-111 and its N-demethylated derivatives (the NHCH3 and NH2 analogues) against SJ-BT45 medulloblastoma xenografts in scid mice revealed that the secondary amine metabolite is at least as active as ARC-111 in vivo, although the primary amine derivative was significantly less potent."
5.	Breast Neoplasms (Breast Cancer) 12/01/2003 - "Unlike CPT, ARC-111 is not a substrate for the ATP-binding cassette transporter breast cancer resistance protein. "

Related Drugs and Biologics

1.	Topotecan (Hycamtin)
2.	Irinotecan (Camptosar)
3.	Proteins (Proteins, Gene)
4.	Topoisomerase I Inhibitors
5.	Ubiquitin
6.	ATP-Binding Cassette Transporters (ABC Transporters)
7.	Nocodazole
8.	Oxygen (Dioxygen)
9.	Type I DNA Topoisomerases (Topoisomerase I)
10.	Camptothecin