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PX-6518

a triterpenoid saponin extract (PX-6518) from the plant Maesa balansae against visceral leishmania species; structure in first source

Networked: 2 relevant articles (2 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Carbohydrates: 22023
- Glycosides: 2119
  - Saponins: 2867
    - PX-6518: 2
Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Triterpenes: 2493
      - PX-6518: 2

Experts

1.	Cos, Paul: 2 articles (02/2011 - 01/2004)
2.	Maes, Louis: 2 articles (02/2011 - 01/2004)
3.	Deschacht, Maartje: 1 article (02/2011)
4.	Hendrickx, Sarah: 1 article (02/2011)
5.	Inocêncio da Luz, Raquel Andreia: 1 article (02/2011)
6.	Van Assche, Tim: 1 article (02/2011)
7.	Vermeersch, Marieke: 1 article (02/2011)
8.	De Kimpe, Norbert: 1 article (01/2004)
9.	Germonprez, Nils: 1 article (01/2004)
10.	Quirijnen, Ludo: 1 article (01/2004)

Related Diseases

1.	Cutaneous Leishmaniasis 02/01/2011 - "This study demonstrates that PX-6518 possesses potent and broad-spectrum prophylactic and curative efficacy against cutaneous leishmaniasis in the BALB/c mouse model. "
2.	Infections 01/01/2004 - "A single dose of PX-6518 at 2.5 mg/kg administered 5 days before infection was still 100% effective in preventing liver infection, suggesting a particularly long residual action. "
3.	Body Weight (Weight, Body) 02/01/2011 - "mexicana) and subcutaneously treated with PX-6518 [1-10 mg/kg body weight (BW)] or Pentostam(®) (250 mg/kg BW Sb(V) eq). "

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